MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD.
MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD.
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DOI：
10.1016/j.neurobiolaging.2009.11.006
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发表时间：
2011-10
影响因子：
4.2
通讯作者：
deToledo-Morrell L
中科院分区：
文献类型：
--
作者：
George S;Mufson EJ;Leurgans S;Shah RC;Ferrari C;deToledo-Morrell L
无名质 (SI) 包含 Meynert 基底核，为整个皮质罩和杏仁核提供主要的胆碱能神经支配；基底核神经元的退化与阿尔茨海默病（AD）的认知能力下降有关。然而，SI萎缩是否发生在遗忘性轻度认知障碍（aMCI）个体中尚未得到彻底的体内检查。在本研究中，我们开发了一种新协议来测量磁共振成像 (MRI) 扫描中 SI 的体积变化。参与者包括 27 名没有认知障碍 (NCI) 的老年对照组； 33 名 aMCI 患者；以及 19 名轻度 AD 患者。 SI 体积在三个连续无间隙 1 毫米厚的冠状切片上追踪。结果显示，与 NCI 和 aMCI 参与者相比，轻度 AD 组的 SI 体积显着减少；然而，NCI 和 aMCI 组之间没有差异。此外，即使注意力受到控制，SI 量的减少也与陈述性记忆任务的表现受损有关。
The substantia innominata (SI) contains the nucleus basalis of Meynert, which provides the major cholinergic innervation to the entire cortical mantel and the amygdala; degeneration of nucleus basalis neurons correlates with cognitive decline in Alzheimer’s disease (AD). However, whether SI atrophy occurs in individuals with amnestic mild cognitive impairment (aMCI) has not been examined thoroughly in vivo. In the present study, we developed a new protocol to measure volumetric changes in the SI from magnetic resonance imaging (MRI) scans. Participants consisted of 27 elderly controls with no cognitive impairment (NCI); 33 individuals with aMCI; and 19 patients with mild AD. SI volumes were traced on three consecutive gapless 1 mm thick coronal slices. Results showed that SI volume was significantly reduced in the mild AD group compared to both NCI and aMCI participants; however, the NCI and aMCI groups did not differ from each other. Furthermore, a decrease in SI volume was related to impaired performance on declarative memory tasks even when attention was controlled.
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影响因子：
1.9
作者：
BAXTER, MG;BUCCI, DJ;GALLAGHER, M
通讯作者：
GALLAGHER, M
影响因子：
9.9
作者：
Devanand, D. P.;Pradhaban, G.;de Leon, M. J.
通讯作者：
de Leon, M. J.
影响因子：
5.7
作者：
Bennett, DA;Schneider, JA;Wilson, RS
通讯作者：
Wilson, RS
影响因子：
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作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR
影响因子：
1.5
作者：
GROBER, E;BUSCHKE, H
通讯作者：
BUSCHKE, H