Minireview: DNA replication in plant mitochondria.

Minireview: DNA replication in plant mitochondria.
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DOI:
10.1016/j.mito.2014.03.008
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发表时间:
2014-11
期刊:
影响因子:
4.4
通讯作者:
Nielsen, Brent L.
Nielsen, Brent L.
中科院分区:
生物学3区
文献类型:
--
作者:
Cupp, John D.;Nielsen, Brent L.

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与大多数其他生物相比,高等植物线粒体基因组表现出更大的结构复杂性。与后生动物线粒体DNA (mtDNA)复制的特征不同,对植物线粒体DNA复制的机制和蛋白质的理解仍然不清楚。已经鉴定出几种植物mtDNA复制蛋白,包括DNA聚合酶、DNA引物酶/解旋酶和辅助蛋白。线粒体动力学、基因组结构以及提供至少部分冗余的双靶点和双功能蛋白质的复杂性表明,与大多数后生动物使用的复制机制相比,植物具有维持和复制mtDNA的独特模式。
Higher plant mitochondrial genomes exhibit much greater structural complexity as compared to most other organisms. Unlike well-characterized metazoan mitochondrial DNA (mtDNA) replication, an understanding of the mechanism(s) and proteins involved in plant mtDNA replication remains unclear. Several plant mtDNA replication proteins, including DNA polymerases, DNA primase/helicase, and accessory proteins have been identified. Mitochondrial dynamics, genome structure, and the complexity of dual-targeted and dual-function proteins that provide at least partial redundancy suggest that plants have a unique model for maintaining and replicating mtDNA when compared to the replication mechanism utilized by most metazoan organisms.
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