A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group.
A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group.
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中国土家族遗传变异和群体结构分析的 30-InDel 分析
DOI：
10.1038/srep36842
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发表时间：
2016-11-11
影响因子：
4.6
通讯作者：
Tai F
中科院分区：
文献类型：
--
作者：
Shen C;Zhu B;Yao T;Li Z;Zhang Y;Yan J;Wang B;Bie X;Tai F
本研究在多重系统中同时扩增了30个常染色体插入和缺失多态性位点，并对236个无亲缘关系的健康土家族个体进行了基因分型，获得了它们的等位基因频率和若干法医学参数。经Bonferroni校正后，所有基因座均处于Hardy-Weinberg平衡，所有成对基因座均未表现出显著的连锁不平衡。这些位点被观察到是相对翔实和鉴别，相当有效的法医应用。比较了土家族群体与其他参考群体30个位点的等位基因频率，分子方差分析结果表明，土家族群体与上海汉人的差异最小，与西班牙中部人群的差异最大，有22个位点。采用主成分分析、结构程序聚类和邻居连接树分析了土家族与其他15个居群的遗传关系。
In the present study, thirty autosomal insertion and deletion polymorphic loci were simultaneously amplified and genotyped in a multiplex system, and their allelic frequencies as well as several forensic parameters were obtained in a sample of 236 unrelated healthy Tujia individuals. All the loci were in Hardy-Weinberg equilibrium after applying a Bonferroni correction and all pair-wise loci showed no significant linkage disequilibrium. These loci were observed to be relatively informative and discriminating, quite efficient for forensic applications. Allelic frequencies of 30 loci were compared between the Tujia group and other reference populations, and the results of analysis of molecular variance indicated the Tujia group showed the least significant differences with the Shanghai Han at one locus, and the most with Central Spanish population at 22 loci. We analyzed the population genetic structure by the principal component analysis, the clustering of STRUCTURE program and a Neighbor-Joining tree, and then evaluated the genetic relationships among Tujia and other 15 populations.
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影响因子：
2.7
作者：
WALSH, PS;METZGER, DA;HIGUCHI, R
通讯作者：
HIGUCHI, R
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影响因子：
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作者：
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