The relationship between blood pressure and cognitive function.
The relationship between blood pressure and cognitive function.
复制标题
DOI：
10.1038/nrcardio.2010.161
复制
发表时间：
2010-12
影响因子：
49.6
通讯作者：
Hajjar, Ihab
中科院分区：
文献类型：
--
作者：
Novak, Vera;Hajjar, Ihab
老年人血压（BP）与认知结果之间的关系对全球卫生保健具有重要意义。高血压和低血压都会影响脑灌注并使认知结果恶化。高血压和其他血管危险因素的存在与执行功能和注意力测试中的表现下降有关。脑血管储备已成为监测压力-灌注-认知关系的潜在生物标志物。血管储备能力下降可导致神经血管耦合受损和认知能力下降。中年的内皮功能障碍、微血管疾病和血管疾病也可能在晚年认知能力下降的多种疾病的表现和严重程度中起重要作用。然而，关于抗高血压治疗在长期预防认知能力下降中的作用仍然存在疑问。在这篇综述中，我们讨论了潜在的病理生理学和现有的证据，支持血管因素在晚年认知能力下降中的作用。
The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with decreased performance in executive function and attention tests. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure–perfusion–cognition relationships. A decline in vascular reserve capacity can lead to impaired neurovascular coupling and decreased cognitive ability. Endothelial dysfunction, microvascular disease, and mascrovascular disease in midlife could also have an important role in the manifestations and severity of multiple medical conditions underlying cognitive decline late in life. However, questions remain about the role of antihypertensive therapies for long-term prevention of cognitive decline. In this Review, we address the underlying pathophysiology and the existing evidence supporting the role of vascular factors in late-life cognitive decline.
登录
查看更多内容
影响因子：
8.3
作者：
Guo, Xinxin;Pantoni, Leonardo;Skoog, Ingmar
通讯作者：
Skoog, Ingmar
影响因子：
2.4
作者：
Cherbuin, Nicolas;Reglade-Meslin, Chantal;Anstey, Kaarin J.
通讯作者：
Anstey, Kaarin J.
影响因子：
8.3
作者：
AASLID, R;LINDEGAARD, KF;NORNES, H
通讯作者：
NORNES, H
影响因子：
9.6
作者：
BULLOCK, R;MENDELOW, AD;ALLARDICE, G
通讯作者：
ALLARDICE, G
影响因子：
2.7
作者：
Fogari, R;Mugellini, A;Preti, P
通讯作者：
Preti, P