Electrical impedance myography: Background, current state, and future directions.
Electrical impedance myography: Background, current state, and future directions.
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DOI：
10.1002/mus.21362
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发表时间：
2009-12
期刊：
影响因子：
3.4
通讯作者：
Rutkove, Seward B.
中科院分区：
文献类型：
--
作者：
Rutkove, Seward B.
电阻抗肌电图（EIM）是一种新的非侵入性技术，用于评估神经肌肉疾病，依赖于高频，低强度电流的应用和测量。EIM评估疾病引起的肌肉正常组成和结构的变化，包括肌细胞萎缩和损失、水肿、神经再支配以及肌内膜结缔组织和脂肪的沉积。通过应用单频电流，EIM可用于帮助对神经肌肉疾病的严重程度进行分级。在所施加的频率的频谱上以及在相对于主要肌纤维方向的多个方向上的电流流动下评估电阻抗可以提供肌肉状况的更完整的图片。EIM有望作为疾病状态的指标，因此可用于临床试验工作和监测个体患者的治疗效果;最终，它也可能找到诊断应用。目前的工作重点是深入了解阻抗变化的基本机制，研究各种临床背景下的EIM，并进一步完善EIM数据采集和分析的方法。
Electrical impedance myography (EIM) is a new non-invasive technique for the evaluation of neuromuscular disease that relies upon the application and measurement of high-frequency, low-intensity electrical current. EIM assesses disease-induced changes to muscle’s normal composition and architecture, including myocyte atrophy and loss, edema, reinnervation, and the deposition of endomysial connective tissue and fat. With application of single-frequency electrical current, EIM can be used to help grade the severity of neuromuscular disease. Assessing electrical impedance across a spectrum of applied frequencies and with current flow at multiple orientations relative to the major muscle fiber direction can provide a more complete picture of muscle condition. EIM holds the promise of serving as an indicator of disease status, thus being useful in clinical trials work and in monitoring effectiveness of treatment in individual patients; ultimately, it may also find diagnostic application. Ongoing efforts have been focused on obtaining a deeper understanding of the basic mechanisms of impedance change, studying EIM in a variety of clinical contexts, and further refining the methods of EIM data acquisition and analysis.
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