Adapting to climate with limited genetic diversity: Nucleotide, DNA methylation and microbiome variation among populations of the social spider Stegodyphus dumicola.
Adapting to climate with limited genetic diversity: Nucleotide, DNA methylation and microbiome variation among populations of the social spider Stegodyphus dumicola.
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DOI：
10.1111/mec.16696
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发表时间：
2022-11
影响因子：
4.9
通讯作者：
Bilde, Trine
中科院分区：
文献类型：
--
作者：
Aagaard, Anne;Liu, Shenglin;Tregenza, Tom;Lund, Marie Braad;Schramm, Andreas;Verhoeven, Koen J. F.;Bechsgaard, Jesper;Bilde, Trine
关键词：
了解遗传和非遗传变异在调节表型中的作用，对于我们了解对当地条件和环境变化的适应性反应至关重要，特别是在种群遗传多样性如此之低的物种中，这可能会限制它们的进化潜力。揭开种群对环境特异性反应的分子机制的第一步是开展环境关联研究。我们将气候变化与遗传、表观遗传和微生物组变异联系在一起，研究了一种具有极低遗传多样性的社会性蜘蛛种群。我们发现了与环境变化密切相关的遗传变异，特别是与平均温度密切相关，这种模式与当地适应一致。许多基因的DNA甲基化变异与一系列广泛的气候参数密切相关，从而揭示了一种与遗传变异不同的关联模式，遗传变异与更有限范围的气候参数密切相关。DNA甲基化水平在很大程度上独立于顺式遗传变异和整体遗传群体结构，这表明DNA甲基化可以作为一种独立的机制发挥作用。微生物组组成也与环境变化相关，但与降水相关的气候因子相关性最强。我们的研究结果表明，遗传和非遗传机制在塑造对当地环境的表型反应中都起着重要作用。
Understanding the role of genetic and nongenetic variants in modulating phenotypes is central to our knowledge of adaptive responses to local conditions and environmental change, particularly in species with such low population genetic diversity that it is likely to limit their evolutionary potential. A first step towards uncovering the molecular mechanisms underlying population‐specific responses to the environment is to carry out environmental association studies. We associated climatic variation with genetic, epigenetic and microbiome variation in populations of a social spider with extremely low standing genetic diversity. We identified genetic variants that are associated strongly with environmental variation, particularly with average temperature, a pattern consistent with local adaptation. Variation in DNA methylation in many genes was strongly correlated with a wide set of climate parameters, thereby revealing a different pattern of associations than that of genetic variants, which show strong correlations to a more restricted range of climate parameters. DNA methylation levels were largely independent of cis‐genetic variation and of overall genetic population structure, suggesting that DNA methylation can work as an independent mechanism. Microbiome composition also correlated with environmental variation, but most strong associations were with precipitation‐related climatic factors. Our results suggest a role for both genetic and nongenetic mechanisms in shaping phenotypic responses to local environments.
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影响因子：
3.3
作者：
Jensen JD;Bachtrog D
通讯作者：
Bachtrog D
影响因子：
7.7
作者：
Dubin MJ;Zhang P;Meng D;Remigereau MS;Osborne EJ;Paolo Casale F;Drewe P;Kahles A;Jean G;Vilhjálmsson B;Jagoda J;Irez S;Voronin V;Song Q;Long Q;Rätsch G;Stegle O;Clark RM;Nordborg M
通讯作者：
Nordborg M
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
5.2
作者：
Dahlgaard, J;Loeschcke, V;Justesen, J
通讯作者：
Justesen, J
影响因子：
3.1
作者：
Coates, Brad S.;Sumerford, Douglas V.;Lewis, Leslie C.
通讯作者：
Lewis, Leslie C.