Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens.
Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens.
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特发性艾滋病肠病和胃肠道机会病原体的治疗。
DOI：
10.1053/j.gastro.2008.12.073
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发表时间：
2009-05
期刊：
影响因子：
29.4
通讯作者：
Day LW
中科院分区：
文献类型：
--
作者：
Cello JP;Day LW
自30多年前发现人类免疫缺陷病毒（HIV）以来，获得性免疫缺陷综合征（AIDS）患者的腹泻已被证明是诊断和治疗的挑战。这组患者腹泻的主要病因是感染性病原体，包括病毒、细菌、原生动物、寄生虫和真菌生物。在许多情况下，高效抗逆转录病毒疗法仍然是艾滋病和艾滋病相关腹泻治疗的基石，但随着新病原体的发现，已经开发了其他靶向疗法;然而，一些感染仍然是治疗挑战。一旦可识别的感染以及腹泻的其他原因被调查和排除，一个独特的实体称为艾滋病肠病可以诊断。这种疾病被称为特发性、病原体阴性腹泻，已被广泛研究。非典型的病毒病原体，包括HIV本身，以及炎症和免疫反应是其潜在的主要原因。虽然艾滋病肠病可以构成一个诊断挑战，但治疗也是如此。高效抗逆转录病毒治疗，营养补充，电解质替代，针对感染的靶向治疗（如有指征），以及控制症状的药物都是治疗方案的关键要素。重要的是，胃肠病学家、传染病医生、艾滋病专家、肿瘤学和外科医生之间的多学科方法对许多患者是必要的。
Diarrhea in patients with acquired immune deficiency syndrome (AIDS) has proven to be both a diagnostic and treatment challenge since the discovery of the human immunodeficiency virus (HIV) virus more than 30 years ago. Among the main etiologies of diarrhea in this group of patients are infectious agents that span the array of viruses, bacteria, protozoa, parasites, and fungal organisms. In many instances, highly active antiretroviral therapy remains the cornerstone of therapy for both AIDS and AIDS-related diarrhea, but other targeted therapies have been developed as new pathogens are identified; however, some infections remain treatment challenges. Once identifiable infections as well as other causes of diarrhea are investigated and excluded, a unique entity known as AIDS enteropathy can be diagnosed. Known as an idiopathic, pathogen-negative diarrhea, this disease has been investigated extensively. Atypical viral pathogens, including HIV itself, as well as inflammatory and immunologic responses are potential leading causes of it. Although AIDS enteropathy can pose a diagnostic challenge so too does the treatment of it. Highly active antiretroviral therapy, nutritional supplementation, electrolyte replacements, targeted therapy for infection if indicated, and medications for symptom control all are key elements in the treatment regimen. Importantly, a multidisciplinary approach among the gastroenterologist, infectious disease physician, HIV specialists, oncology, and surgery is necessary for many patients.
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影响因子：
6.4
作者：
Coyle, C;Kent, M;Weiss, LM
通讯作者：
Weiss, LM
DOI：
10.4269/ajtmh.2000.63.121
发表时间：
2000-09-01
影响因子：
3.3
作者：
Conteas, CN;Berlin, OGW;Pruthi, JS
通讯作者：
Pruthi, JS
影响因子：
3.7
作者：
Delezay, O;Yahi, N;Fantini, J
通讯作者：
Fantini, J
影响因子：
4.6
作者：
Dandekar, Satya
通讯作者：
Dandekar, Satya
影响因子：
158.5
作者：
GROHMANN, GS;GLASS, RI;BRYAN, RT
通讯作者：
BRYAN, RT