An integrated approach to diabetic retinopathy research.
An integrated approach to diabetic retinopathy research.
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DOI:
10.1001/archophthalmol.2010.362
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发表时间:
2011-02
影响因子:
--
通讯作者:
Jackson, Gregory R.
中科院分区:
文献类型:
--
作者:
Gardner, Thomas W.;Abcouwer, Steven F.;Barber, Alistair J.;Jackson, Gregory R.
This review discusses the pathophysiology of diabetic retinopathy related to direct effects of loss of insulin receptor action and metabolic dysregulation on the retina. The resulting sensory neuropathy can be diagnosed by structural and functional tests in patients with mild nonproliferative diabetic retinopathy. Research teams can collaborate to integrate ocular and systemic factors that impair vision and design strategies to maintain retinal function in persons with diabetes. Evolving concepts may lead to inclusion of tests of retinal function in the detection of diabetic retinopathy and neuroprotective strategies to preserve vision for persons with diabetes.
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