Sjögren's Versus Non-Sjögren's Ocular Features: Similar Symptoms, But Significantly Worse Signs.
Sjögren's Versus Non-Sjögren's Ocular Features: Similar Symptoms, But Significantly Worse Signs.
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DOI：
10.1167/iovs.65.1.23
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发表时间：
2024-01-02
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
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检查干燥病国际合作临床联盟队列参与者的眼部体征和症状，并对干燥病 (SjD) 状态进行比较。我们的研究人群包括 3380 名 Sjögren 国际合作临床联盟参与者，他们没有缺失与本研究相关的数据。参与者的 SjD 状态使用更新的 2016 年美国风湿病学院/欧洲抗风湿病联盟 SjD 分类标准进行评估。参与者完成了眼部症状的基线调查问卷并接受了眼部检查。评估了 SjD 和非 SjD 组之间眼部体征和症状的差异。我们使用多变量线性和线性混合效应模型来研究 SjD 对眼表疾病指数 6 和 OSS 的影响。在 1532 名被分类为 SjD 的参与者中，他们的眼表疾病指数 6 与被分类为非 SjD 的参与者在临床上没有差异（调整后的差异，-0.97；95% 置信区间，-1.52 至 -0.41）。然而，与非 SjD 参与者相比，SjD 参与者表现出较高的眼部染色评分（调整后差异，3.47；95% 置信区间，3.36–3.57；P < 0.001）。此外，SjD 与眼部症状发生率增加相关，例如泪膜破裂时间缩短、Schirmer I 试验异常和角膜异常，并且与更强烈的角膜和结膜染色以及额外的角膜染色点密切相关。与非 SjD 相比，SjD 与更高的眼部体征和病理风险相关，但眼部症状仍然相似。此外，角膜异常和角膜染色模式可以作为识别 SjD 相关干眼症的潜在生物标志物。
To examine the ocular signs and symptoms in participants of the Sjögren's International Collaborative Clinical Alliance cohort, and to compare them across Sjögren's disease (SjD) status. Our study population comprised 3380 Sjögren's International Collaborative Clinical Alliance participants who had no missing data relevant to this study. Participants’ SjD status was assessed using the updated 2016 American College of Rheumatism/European League Against Rheumatism SjD classification criteria. Participants completed baseline questionnaires of ocular symptoms and underwent ocular examinations. Differences in the ocular signs and symptoms between SjD and non-SjD groups were assessed. We used multivariable linear and linear mixed-effects models to investigate the impact of SjD on Ocular Surface Disease Index-6 and OSS. Among 1532 participants classified as SjD, their Ocular Surface Disease Index-6 did not clinically differ from those classified as non-SjD (adjusted difference, −0.97; 95% confidence interval, −1.52 to −0.41). However, SjD participants exhibited an elevated ocular staining score (adjusted difference, 3.47; 95% confidence interval, 3.36–3.57; P < 0.001) compared with non-SjD participants. In addition, SjD was associated with increased odds of ocular signs, such as reduced tear break-up time, abnormal Schirmer I test, and corneal abnormalities, and was strongly related to more intense corneal and conjunctival staining, as well as additional corneal staining points. SjD is associated with a higher risk of ocular signs and pathology compared with non-SjD, whereas ocular symptoms remain similar. In addition, corneal abnormalities and corneal staining patterns could serve as a potential biomarker in identifying SjD-related dry eye.
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