Corneal nerve structure in patients with primary Sjögren's syndrome in China.
Corneal nerve structure in patients with primary Sjögren's syndrome in China.
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DOI：
10.1186/s12886-021-01967-7
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发表时间：
2021-05-12
影响因子：
2
通讯作者：
Zhao M
中科院分区：
文献类型：
--
作者：
Li F;Zhang Q;Ying X;He J;Jin Y;Xu H;Cheng Y;Zhao M
本研究的目的是评估中国原发性干燥综合征患者角膜基底下神经的活体共焦显微镜形态及其与临床参数的关系。这是一项病例对照研究，包括22名患有原发性干燥综合征（pSS）的干眼病（DED）患者和20名患有非干燥综合征（NSS）的对照受试者。每例患者均接受了眼表疾病的评估，包括泪膜破裂时间（TBUT）、非侵入性泪膜破裂时间（NIKBUT）、非侵入性泪半月板高度（NIKTMH）、角膜染色（国家眼科研究所量表，NEI）、Schirmer I试验、睑缘描记术和使用体内共焦显微镜（IVCM）进行的角膜基底下神经分析。每例受试者的右眼均纳入本研究。SS患者的TBUT（P = 0.009）和Schirmer I试验结果（P = 0.028）较Nursing组短。但两组NIKBUT差异无统计学意义（P = 0.393）。SS组的基底下神经密度、神经根数和迂曲度均显著低于NNNES组（P = 0.001，P < 0.001和P = 0.039）。在SS组中，平均神经长度与年龄和Schirmer I检验相关（分别为r =-0.519，P = 0.013和r = 0.463，P = 0.035）。角膜染色与神经密度和神经数量相关（分别为r =-0.534，P = 0.013和r =-0.487，P = 0.025）。干燥综合征干眼（SSDE）患者比非干燥综合征干眼（NND）患者具有更严重的临床干眼参数。SSDE患者角膜基底下神经密度和数目较NINST患者明显减少。在线版本包含补充材料，可通过10.1186/s12886-021-01967-7获得。
The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China. This was a case control study of 22 dry eye disease (DED) patients with primary Sjögren’s syndrome (pSS) and 20 control subjects with non-Sjögren dry eye disease (NSDE). Each patient underwent an evaluation of ocular surface disease using the tear film break-up time (TBUT), noninvasive tear film break-up time (NIKBUT), noninvasive tear meniscus height (NIKTMH), corneal staining (National Eye Institute scale, NEI), Schirmer I test, meibography, and corneal subbasal nerve analysis with in vivo confocal microscopy (IVCM). The right eye of each subject was included in this study. SS patients showed a shorter TBUT (P = 0.009) and Schirmer I test results (P = 0.028) than the NSDE group. However, there was no significant difference in NIKBUT between the two groups (P = 0.393). The nerve density of subbasal nerves, number of nerves and tortuosity of the SS group were significantly lower than those of the NSDE group (P = 0.001, P < 0.001 and P = 0.039, respectively). In the SS group, the mean nerve length was correlated with age and the Schirmer I test (r = − 0.519, P = 0.013 and r = 0.463, P = 0.035, respectively). Corneal staining was correlated with nerve density and the number of nerves (r = − 0.534, P = 0.013 and r = − 0.487, P = 0.025, respectively). Sjögren syndrome dry eye (SSDE) patients have more severe clinical dry eye parameters than non-Sjögren dry eye disease (NSDE) patients. Compared with NSDE patients, we found that SSDE patients showed decreased corneal subbasal nerve density and numbers. The online version contains supplementary material available at 10.1186/s12886-021-01967-7.
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影响因子：
3.4
作者：
GARCIAHIRSCHFELD, J;LOPEZBRIONES, LG;BELMONTE, C
通讯作者：
BELMONTE, C
影响因子：
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作者：
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作者：
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作者：
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影响因子：
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作者：
Shimazaki, J;Goto, E;Tsubota, K
通讯作者：
Tsubota, K