Mitochondrial DNA diversity of modern, ancient and wild sheep(Ovis gmelinii anatolica) from Turkey: new insights on the evolutionary history of sheep.
Mitochondrial DNA diversity of modern, ancient and wild sheep(Ovis gmelinii anatolica) from Turkey: new insights on the evolutionary history of sheep.
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DOI：
10.1371/journal.pone.0081952
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Togan I
中科院分区：
文献类型：
--
作者：
Demirci S;Koban Baştanlar E;Dağtaş ND;Pişkin E;Engin A;Ozer F;Yüncü E;Doğan SA;Togan I
为了更好地理解绵羊的进化史，本研究将现代土耳其本土家羊（n = 628）、现代野生羊（Ovis gmelinii anatolica） （n = 30）和来自Kilis Oylum Höyük的古代家羊（n = 33）的线粒体（mt） DNA多态性与文献积累的数据进行了比较分析。mtDNA控制区（CR）序列的第二个和随后的重复单元长度（75 bp/76 bp）将在家养绵羊中观察到的5个单倍群（hpg）区分为两个遗传簇，这已经被其他mtDNA标记所暗示：第一簇由HPGs A、B、D组成，第二簇含有HPGs C、e。为了证明野生绵羊和家养绵羊单倍群之间的遗传亲缘关系，我们在中间连接网络上对它们的部分细胞色素B序列进行了检测。上述两个平行但更广泛的聚类也被观察到存在于山羊个体网络中的家养单倍群。今天的野生雌鳗似乎分布在两个部分重叠的地理区域，与它们所属的遗传集群平行（第一个集群位于整体分布的西部）。因此，分析表明，家羊可能是两个母系不同的古山羊种群的产物。此外，山羊个体表现出HPG a单倍型（n = 22）和另一个HPG a单倍型（n = 8），这在现代家羊中没有观察到。新观测到的HPG E成员（n = 11）显示出膨胀的迹象。对古代和现代mtDNA的研究表明，在希腊化时期开始后的一段时间内，安纳托利亚东南部的HPG C频率从6%增加到22%，比公元前500年（Common Era）早。
In the present study, to contribute to the understanding of the evolutionary history of sheep, the mitochondrial (mt) DNA polymorphisms occurring in modern Turkish native domestic (n = 628), modern wild (Ovis gmelinii anatolica) (n = 30) and ancient domestic sheep from Oylum Höyük in Kilis (n = 33) were examined comparatively with the accumulated data in the literature. The lengths (75 bp/76 bp) of the second and subsequent repeat units of the mtDNA control region (CR) sequences differentiated the five haplogroups (HPGs) observed in the domestic sheep into two genetic clusters as was already implied by other mtDNA markers: the first cluster being composed of HPGs A, B, D and the second cluster harboring HPGs C, E. To manifest genetic relatedness between wild Ovis gmelinii and domestic sheep haplogroups, their partial cytochrome B sequences were examined together on a median-joining network. The two parallel but wider aforementioned clusters were observed also on the network of Ovis gmelenii individuals, within which domestic haplogroups were embedded. The Ovis gmelinii wilds of the present day appeared to be distributed on two partially overlapping geographic areas parallel to the genetic clusters that they belong to (the first cluster being in the western part of the overall distribution). Thus, the analyses suggested that the domestic sheep may be the products of two maternally distinct ancestral Ovis gmelinii populations. Furthermore, Ovis gmelinii anatolica individuals exhibited a haplotype of HPG A (n = 22) and another haplotype (n = 8) from the second cluster which was not observed among the modern domestic sheep. HPG E, with the newly observed members (n = 11), showed signs of expansion. Studies of ancient and modern mtDNA suggest that HPG C frequency increased in the Southeast Anatolia from 6% to 22% some time after the beginning of the Hellenistic period, 500 years Before Common Era (BCE).
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影响因子：
2.8
作者：
Cai, Da-Wei;Han, Lu;Zhu, Hong
通讯作者：
Zhu, Hong
DOI：
10.1098/rspb.2002.1975
发表时间：
2002-05-07
影响因子：
4.7
作者：
Hiendleder, S;Kaupe, B;Janke, A
通讯作者：
Janke, A
影响因子：
3.8
作者：
Meadows, J. R. S.;Hiendleder, S.;Kijas, J. W.
通讯作者：
Kijas, J. W.
影响因子：
9.8
作者：
Kijas JW;Lenstra JA;Hayes B;Boitard S;Porto Neto LR;San Cristobal M;Servin B;McCulloch R;Whan V;Gietzen K;Paiva S;Barendse W;Ciani E;Raadsma H;McEwan J;Dalrymple B;International Sheep Genomics Consortium Members
通讯作者：
International Sheep Genomics Consortium Members
影响因子：
3.1
作者：
Hiendleder, S;Mainz, K;Lewalski, H
通讯作者：
Lewalski, H