Role of procalcitonin and C-reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia.
Role of procalcitonin and C-reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia.
复制标题
从2009年H1N1病毒性肺炎开始，促阳性素和C反应蛋白在分化混合细菌感染中的作用。
DOI：
10.1111/j.1750-2659.2011.00244.x
复制
发表时间：
2011-11
影响因子：
4.4
通讯作者：
Kim W
中科院分区：
文献类型：
--
作者：
Ahn S;Kim WY;Kim SH;Hong S;Lim CM;Koh Y;Lim KS;Kim W
请引用这篇论文：Ahn et al.（2011）降钙素原和C反应蛋白在区分混合细菌感染与2009年H1N1病毒性肺炎中的作用。流感和其他呼吸道病毒5（6），398-403。 背景在流感大流行期间，混合细菌感染是导致发病率和死亡率的重要因素。 我们评估了降钙素原（PCT）和C反应蛋白（CRP）在区分细菌和2009年H1N1流感混合感染与2009年H1N1流感单独感染引起的肺炎中的作用。 方法回顾性收集2009年H1N1流感大流行期间7个月的数据。 纳入了急诊科就诊并诊断为2009年H1N1感染引起的社区获得性肺炎的患者（n = 60）。 结果16例细菌病毒混合感染性肺炎患者血清PCT和CRP水平明显高于44例单纯H1N1流感肺炎患者（P分别为0. 019和0. 022）。 PCT> 1.5ng/ml，CRP> 10 mg/dl时，诊断混合菌感染性肺炎的敏感性和特异性分别为56%和84%; 联合应用PCT和CRP诊断的敏感性和特异性分别为50%和93%。 结论降钙素原和CRP单独及联合检测对2009年甲型H1N1流感期间混合细菌感染性肺炎的诊断能力中等。 考虑到高特异性，低CRP和PCT结果的组合可能表明肺炎不太可能由混合细菌感染引起。
Please cite this paper as: Ahn et al. (2011) Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia. Influenza and Other Respiratory Viruses 5(6), 398–403. Background Mixed bacterial infection is an important contributor to morbidity and mortality during influenza pandemics. We evaluated procalcitonin (PCT) and C‐reactive protein (CRP) in differentiating pneumonia caused by mixed bacterial and 2009 H1N1 influenza infection from 2009 H1N1 influenza infection alone. Methods Data were collected retrospectively over a 7‐month period during the 2009 H1N1 influenza pandemic. Patients visiting emergency department and diagnosed as community‐acquired pneumonia caused by 2009 H1N1 infection were included (n = 60). Results Mixed bacterial and viral infection pneumonia (n = 16) had significantly higher PCT and CRP levels than pneumonia caused by 2009 H1N1 influenza alone (n = 44, P = 0·019, 0·022 respectively). The sensitivity and specificity for detection of mixed bacterial infection pneumonia was 56% and 84% for PCT > 1·5 ng/ml, and 69% and 63% for CRP > 10 mg/dl. Using PCT and CRP in combination, the sensitivity and specificity were 50% and 93%, respectively. Conclusion Procalcitonin and CRP alone and their combination had a moderate ability to detect pneumonia of mixed bacterial infection during the 2009 H1N1 pandemic. Considering high specificity, combination of low CRP and PCT result may suggest that pneumonia is unlikely to be caused by mixed bacterial infection.
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DOI：
10.1086/591708
发表时间：
2008-10-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Morens DM;Taubenberger JK;Fauci AS
通讯作者：
Fauci AS
影响因子：
120.7
作者：
Thompson, WW;Shay, DK;Fukuda, K
通讯作者：
Fukuda, K
DOI：
10.1164/rccm.200512-1922oc
发表时间：
2006-07-01
影响因子：
24.7
作者：
Christ-Crain, Miriam;Stolz, Daiana;Mueller, Beat
通讯作者：
Mueller, Beat
影响因子：
--
作者：
Choi, Wook Jin;Kim, Won Young;Koh, Yoinsuck
通讯作者：
Koh, Yoinsuck
影响因子：
11.8
作者：
Chirouze, C;Schuhmacher, H;Hoen, B
通讯作者：
Hoen, B