Evaluation of systemic amyloidosis by scintigraphy with 123I-labeled serum amyloid P component.
Evaluation of systemic amyloidosis by scintigraphy with 123I-labeled serum amyloid P component.
复制标题
使用 123I 标记的血清淀粉样蛋白 P 成分进行闪烁扫描评估系统性淀粉样变性。
DOI：
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复制
发表时间：
1990
影响因子：
158.5
通讯作者：
M. Pepys
中科院分区：
文献类型：
--
作者：
P. Hawkins;J. Lavender;M. Pepys
背景
在系统性淀粉样变性中，疾病的分布和进展很难监测，因为它们只能通过活检来证明。血清淀粉样蛋白 P 成分 (SAP) 是一种正常的循环血浆蛋白，由于其与淀粉样原纤维的特异性结合亲和力而沉积在淀粉样原纤维上。我们研究了标记 SAP 是否可用于定位淀粉样蛋白沉积物。
方法
用碘 123 标记的纯化人类 SAP 被静脉注射给 50 名经活检证实患有系统性淀粉样变性的患者（其中 25 名是 AL（原发性）型，25 名是 AA（继发性）型），以及 26 名对照疾病患者和 10 名健康受试者。 24小时后获得全身图像和局部视图，并以盲法方式读取。
结果
在淀粉样变性患者中，123I-SAP 快速且特异性地定位于淀粉样蛋白沉积物中。获得的闪烁扫描图像具有特征性，似乎可以识别所有 50 名患者的淀粉样蛋白沉积程度。对照患者和健康受试者没有摄取 123I-SAP。所有 AA 型淀粉样变性患者的脾脏均受到影响，而扫描显示仅 AL 型患者的心脏、皮肤、腕部区域和骨髓有摄取。在六名活检呈阴性或不成功的患者中出现了阳性图像；随后在所有六人中，在活检或尸检中都发现了淀粉样蛋白。在连续研究的 11 名患者中，有 9 名观察到进行性淀粉样蛋白沉积。
结论
注射123I-SAP后的闪烁扫描可用于诊断、定位和监测系统性淀粉样变性的程度。
BACKGROUND
In systemic amyloidosis the distribution and progression of disease have been difficult to monitor, because they can be demonstrated only by biopsy. Serum amyloid P component (SAP) is a normal circulating plasma protein that is deposited on amyloid fibrils because of its specific binding affinity for them. We investigated whether labeled SAP could be used to locate amyloid deposits.
METHODS
Purified human SAP labeled with iodine-123 was given intravenously to 50 patients with biopsy-proved systemic amyloidosis--25 with the AL (primary) type and 25 with the AA (secondary) type--and to 26 control patients with disease and 10 healthy subjects. Whole-body images and regional views were obtained after 24 hours and read in a blinded fashion.
RESULTS
In the patients with amyloidosis the 123I-SAP was localized rapidly and specifically in amyloid deposits. The scintigraphic images obtained were characteristic and appeared to identify the extent of amyloid deposition in all 50 patients. There was no uptake of the 123I-SAP by the control patients and the healthy subjects. In all patients with AA amyloidosis the spleen was affected, whereas the scans showed uptake in the heart, skin, carpal region, and bone marrow only in patients with the AL type. Positive images were seen in six patients in whom biopsies had been negative or unsuccessful; in all six, amyloid was subsequently found on biopsy or at autopsy. Progressive amyloid deposition was observed in 9 of 11 patients studied serially.
CONCLUSIONS
Scintigraphy after the injection of 123I-SAP can be used for diagnosing, locating, and monitoring the extent of systemic amyloidosis.
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DOI：
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发表时间：
1981
期刊：
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影响因子：
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DOI：
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DOI：
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影响因子：
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