Seroprevalence of Chikungunya virus and living conditions in Feira de Santana, Bahia-Brazil.
Seroprevalence of Chikungunya virus and living conditions in Feira de Santana, Bahia-Brazil.
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DOI：
10.1371/journal.pntd.0009289
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发表时间：
2021-04
影响因子：
3.8
通讯作者：
Whitworth J
中科院分区：
文献类型：
--
作者：
Teixeira MG;Skalinski LM;Paixão ES;Costa MDCN;Barreto FR;Campos GS;Sardi SI;Carvalho RH;Natividade M;Itaparica M;Dias JP;Trindade SC;Teixeira BP;Morato V;Santana EB;Goes CB;Silva NSJ;Santos CAST;Rodrigues LC;Whitworth J
基孔肯雅热是一种由伊蚊传播的虫媒病毒，2013年在美洲出现，并迅速蔓延到该大陆的几乎每个国家。在巴西，2014年发现了第一批病例，目前已蔓延到该国所有地区，报告了90多万例病例。基孔肯雅热的临床表现从急性自限性形式到致残性慢性形式不等。本研究的目的是估计巴西一个大城市基孔肯雅热感染的血清阳性率，并调查病毒循环和生活条件之间的关系。我们在2016/2017年通过家庭访谈和血清学调查在选定的哨点地区（SA）进行了基于人群的生态研究。样本是随机抽取的1，981人。CHIKV血清阳性率为22.1%（17.1 IgG，2.3 IgM和1.4 IgG和IgM），SA之间的变化范围为2.0%至70.5%。高居住条件SA的血清阳性率显著低于低居住条件SA。CHIKV血清阳性率与人口密度呈正相关（r = 0.2389; p = 0.02033）。该市的血清阳性率比在同一城市中心的CHIKV流行中心进行的研究中观察到的57%低2.6倍。所以，在这种药剂流通四年后，普通人群的群体免疫力相对较低。这表明CHIKV传播可能在该城市持续存在，无论是以地方性形式还是以新的流行病形式，因为媒介侵扰是持续的。此外，生活条件较高的撒哈拉以南非洲血清阳性率明显较低，这表明，除了疾病监测、病媒控制和基本卫生的具体行动外，减少这种感染的发生率还取决于改善人口的一般生活条件。基孔肯雅热是一种由伊蚊传播的病毒引起的疾病。它之所以突出，是因为它可以产生慢性病例和致残形式。这项调查是在巴西的一个大城市进行的，涉及生活条件不同的1，981人/LC，分布在30个城市地区。进行访谈和采血以了解基孔肯雅病毒（CHIKV）的血清阳性率。全球血清阳性率为22.1%，范围为2.0 - 70.5%。血清阳性率最高和最低的地区均为低LC地区，但不同地区的人口密度不同，这与血清阳性率有关。蚊媒指数与血清阳性率无关。我们的结果表明，较低的血清阳性率比另一项调查中进行的震中，这同一个城市的流行。因此，费拉德桑塔纳相当一部分人口易受CHIKV感染。只要LC仍然有利于CHIKV传播媒介的繁殖，病毒可能会继续传播并表现为地方性或流行性。
Chikungunya is an arbovirus, transmitted by Aedes mosquitoes, which emerged in the Americas in 2013 and spread rapidly to almost every country on this continent. In Brazil, where the first cases were detected in 2014, it currently has reached all regions of this country and more than 900,000 cases were reported. The clinical spectrum of chikungunya ranges from an acute self-limiting form to disabling chronic forms. The purpose of this study was to estimate the seroprevalence of chikungunya infection in a large Brazilian city and investigate the association between viral circulation and living condition. We conducted a population-based ecological study in selected Sentinel Areas (SA) through household interviews and a serologic survey in 2016/2017. The sample was of 1,981 individuals randomly selected. The CHIKV seroprevalence was 22.1% (17.1 IgG, 2.3 IgM, and 1.4 IgG and IgM) and varied between SA from 2.0% to 70.5%. The seroprevalence was significantly lower in SA with high living conditions compared to SA with low living condition. There was a positive association between CHIKV seroprevalence and population density (r = 0.2389; p = 0.02033). The seroprevalence in this city was 2.6 times lower than the 57% observed in a study conducted in the epicentre of the CHIKV epidemic of this same urban centre. So, the herd immunity in this general population, after four years of circulation of this agent is relatively low. It indicates that CHIKV transmission may persist in that city, either in endemic form or in the form of a new epidemic, because the vector infestation is persistent. Besides, the significantly lower seroprevalences in SA of higher Living Condition suggest that beyond the surveillance of the disease, vector control and specific actions of basic sanitation, the reduction of the incidence of this infection also depends on the improvement of the general living conditions of the population. Chikungunya is a disease caused by viruses transmitted by Aedes mosquitoes. It stands out because it can produce chronic cases and disabling forms. This survey was conducted in a large city in Brazil, involving 1,981 people living in different living conditions/LC, distributed in 30 urban areas. Interviews and blood collection were performed to know the seroprevalence of chikungunya virus (CHIKV). The global seroprevalence was 22.1%, ranged from 2.0 to 70.5%. The areas where the highest and lowest seroprevalence were of low LC, but population density was different among them, which was related to seroprevalence. The mosquito index was not associated with the seroprevalence. Our results showed that lower seroprevalence than another survey conducted in the epicentre of the epidemic of this same city. So, a considerable proportion of the population of Feira de Santana is susceptible to the CHIKV. Possibly the virus will continue to circulate and manifest itself as endemic or epidemic, as long as LC remain favourable to the reproduction of the transmitting vector of CHIKV.
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影响因子：
3.8
作者：
Fritzell C;Rousset D;Adde A;Kazanji M;Van Kerkhove MD;Flamand C
通讯作者：
Flamand C
影响因子：
11.8
作者：
Prat, Christine M.;Flusin, Olivier;Leparc-Goffart, Isabelle
通讯作者：
Leparc-Goffart, Isabelle
影响因子：
2.7
作者：
Braga C;Luna CF;Martelli CM;de Souza WV;Cordeiro MT;Alexander N;de Albuquerque Mde F;Júnior JC;Marques ET
通讯作者：
Marques ET
DOI：
10.3390/ijerph16101759
发表时间：
2019-05-02
影响因子：
--
作者：
McHale, Thomas C.;Romero-Vivas, Claudia M.;Cano, Jorge
通讯作者：
Cano, Jorge
影响因子：
3.8
作者：
Kikuti M;Cunha GM;Paploski IA;Kasper AM;Silva MM;Tavares AS;Cruz JS;Queiroz TL;Rodrigues MS;Santana PM;Lima HC;Calcagno J;Takahashi D;Gonçalves AH;Araújo JM;Gauthier K;Diuk-Wasser MA;Kitron U;Ko AI;Reis MG;Ribeiro GS
通讯作者：
Ribeiro GS