How and Why the Circadian Clock Regulates Proliferation of Adult Epithelial Stem Cells.
How and Why the Circadian Clock Regulates Proliferation of Adult Epithelial Stem Cells.
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DOI：
10.1093/stmcls/sxad013
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发表时间：
2023-04-25
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First described in the early 20th century, diurnal oscillations in stem cell proliferation exist in multiple internal epithelia, including in the gastrointestinal tract, and in the epidermis. In the mouse epidermis, 3- to 4-fold more stem cells are in S-phase during the night than during the day. More recent work showed that an intact circadian clock intrinsic to keratinocytes is required for these oscillations in epidermal stem cell proliferation. The circadian clock also regulates DNA excision repair and DNA damage in epidermal stem cells in response to ultraviolet B radiation. During skin inflammation, epidermal stem cell proliferation is increased and diurnal oscillations are suspended. Here we discuss possible reasons for the evolution of this stem cell phenomenon. We argue that the circadian clock coordinates intermediary metabolism and the cell cycle in epidermal stem cells to minimize the accumulation of DNA damage from metabolism-generated reactive oxygen species. Circadian disruption, common in modern society, leads to asynchrony between metabolism and the cell cycle, and we speculate this will lead to oxidative DNA damage, dysfunction of epidermal stem cells, and skin aging.
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DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
6
作者：
Bjarnason, GA;Jordan, RCK;Sothern, RB
通讯作者：
Sothern, RB
DOI：
10.18632/aging.100130
发表时间：
2010-03-31
期刊：
Aging
影响因子：
--
作者：
Geyfman M;Andersen B
通讯作者：
Andersen B
影响因子：
64.5
作者：
Chang HC;Guarente L
通讯作者：
Guarente L
影响因子：
3.5
作者：
Duan J;Greenberg EN;Karri SS;Andersen B
通讯作者：
Andersen B