The circadian clock and diseases of the skin.
The circadian clock and diseases of the skin.
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DOI：
10.1002/1873-3468.14192
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发表时间：
2021-10
期刊：
影响因子：
3.5
通讯作者：
Andersen B
中科院分区：
文献类型：
--
作者：
Duan J;Greenberg EN;Karri SS;Andersen B
生物体有一种进化上保守的内部节奏，帮助它们预测和适应环境的日常变化。与大约24小时的明暗周期同步，生物钟的时间由从视网膜发送到视交叉上核的光触发信号设定。其他输入，包括食物摄入，运动和温度，也会影响外周组织（包括皮肤）的生物钟。在这里，我们回顾了核心时钟网络和皮肤的基本生理过程，如稳态，再生，免疫和应激反应之间错综复杂的相互作用。我们举例说明了进食时间对皮肤生物钟和皮肤功能的影响，这是一个以前被忽视的研究领域。然后，我们讨论了与生物钟及其破坏皮肤病，包括皮肤癌，晒伤，脱发，衰老，感染，炎症性皮肤病和伤口愈合。最后，我们强调昼夜节律医学对皮肤病预防和管理的承诺。
Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and adapt to daily changes in the environment. Synchronized to the light-dark cycle with a period of around 24 hours, the timing of the circadian clock is set by light-triggering signals sent from the retina to the suprachiasmatic nucleus. Other inputs, including food intake, exercise, and temperature, also affect clocks in peripheral tissues, including skin. Here, we review the intricate interplay between the core clock network and fundamental physiological processes in skin such as homeostasis, regeneration, immune and stress responses. We illustrate the effect of feeding time on the skin circadian clock and skin function, a previously overlooked area of research. We then discuss works that relate the circadian clock and its disruption to skin diseases, including skin cancer, sunburn, hair loss, aging, infections, inflammatory skin diseases, and wound healing. Finally, we highlight the promise of circadian medicine for skin disease prevention and management.
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