Toward contrast-enhanced microwave-induced thermoacoustic imaging of breast cancer: an experimental study of the effects of microbubbles on simple thermoacoustic targets.
Toward contrast-enhanced microwave-induced thermoacoustic imaging of breast cancer: an experimental study of the effects of microbubbles on simple thermoacoustic targets.
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DOI：
10.1088/0031-9155/54/3/011
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发表时间：
2009-02-07
影响因子：
3.5
通讯作者：
Hagness SC
中科院分区：
文献类型：
--
作者：
Mashal A;Booske JH;Hagness SC
微波诱导热声断层成像（MI-TAT）是一种成像技术，利用微波频率下的介电对比度，同时创建具有超声分辨率的图像。我们建议使用微泡作为介电造影剂，以提高MI-TAT检测乳腺癌的灵敏度。作为这一概念的初步调查，我们实验研究了在何种程度上微波诱导的热声响应的介电目标被修改的存在下，充满空气的玻璃微泡。我们创建了乙二醇与不同重量百分比的微泡的混合物，其特征在于它们的微波性能（0.5-6 GHz）和热声响应时，在3 GHz的微波能量照射。我们的数据表明，微泡大大降低了相对介电常数，电导率，和热声响应的乙二醇混合物。我们假设，微泡到肿瘤部位的间质输注将类似地产生比造影剂前反应更小的热声反应，从而通过使用差分成像技术提高灵敏度。
Microwave-induced thermoacoustic tomography (MI-TAT) is an imaging technique that exploits dielectric contrast at microwave frequencies while creating images with ultrasound resolution. We propose the use of microbubbles as a dielectric contrast agent for enhancing the sensitivity of MI-TAT for breast cancer detection. As an initial investigation of this concept, we experimentally studied the extent to which the microwave-induced thermoacoustic response of a dielectric target is modified by the presence of air-filled glass microbubbles. We created mixtures of ethylene glycol with varying weight percentages of microbubbles and characterized both their microwave properties (0.5-6 GHz) and thermoacoustic response when irradiated with microwave energy at 3 GHz. Our data shows that the microbubbles considerably lowered the relative permittivity, electrical conductivity, and thermoacoustic response of the ethylene glycol mixtures. We hypothesize that the interstitial infusion of microbubbles to a tumor site will similarly create a smaller thermoacoustic response compared to the pre-contrast-agent response, thereby enhancing sensitivity through the use of differential imaging techniques.
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影响因子：
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发表时间：
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影响因子：
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