Invariant NKT cells are required for airway inflammation induced by environmental antigens.
Invariant NKT cells are required for airway inflammation induced by environmental antigens.
复制标题
DOI：
10.1084/jem.20102229
复制
发表时间：
2011-06-06
期刊：
影响因子：
--
通讯作者：
Horner AA
中科院分区：
文献类型：
--
作者：
Wingender G;Rogers P;Batzer G;Lee MS;Bai D;Pei B;Khurana A;Kronenberg M;Horner AA
房屋灰尘含有能够激活小鼠和人类iNKT细胞的抗原，有助于过敏原诱导的气道炎症。不变NKT细胞（iNKT细胞）是T淋巴细胞的一个独特的亚群，可以快速执行效应功能。在这项研究中，我们报告了大多数无菌屋尘提取物（HDEs）测试含有能够激活小鼠和人iNKT细胞的抗原。在依赖于Vα14i NKT细胞的卵清蛋白（OVA）诱导的哮喘模型中，HDEs具有佐剂样特性，因为接种iNKT细胞缺乏疫苗的动物表现出明显的免疫反应减弱和气道炎症。此外，HDEs与OVA联合使用可相互增强Vα14i NKT细胞和肺内常规CD4+ T细胞对细胞因子的合成，表明Th2细胞因子和IL-17A具有深刻的免疫应答协同作用。这些数据表明，iNKT细胞抗原在环境中的分布比先前预期的要广泛得多。此外，由于不同房屋的抗原活性差异很大，他们进一步表明，iNKT细胞对环境抗原的反应，特别是对某些环境的反应，可能促进对传统呼吸道过敏原的致敏。
House dust contains antigens capable of activating mouse and human iNKT cells, contributing to allergen-induced airway inflammation. Invariant NKT cells (iNKT cells) are a unique subset of T lymphocytes that rapidly carry out effector functions. In this study, we report that a majority of sterile house dust extracts (HDEs) tested contained antigens capable of activating mouse and human iNKT cells. HDEs had adjuvant-like properties in an ovalbumin (OVA)-induced asthma model, which were dependent on Vα14i NKT cells, as vaccinated animals deficient for iNKT cells displayed significantly attenuated immune responses and airway inflammation. Furthermore, the administration of HDEs together with OVA mutually augmented the synthesis of cytokines by Vα14i NKT cells and by conventional CD4+ T cells in the lung, demonstrating a profound immune response synergy for both Th2 cytokines and IL-17A. These data demonstrate that iNKT cell antigens are far more widely dispersed in the environment than previously anticipated. Furthermore, as the antigenic activity in different houses varied greatly, they further suggest that iNKT cell responses to ambient antigens, particular to certain environments, might promote sensitization to conventional respiratory allergens.
登录
查看更多内容
影响因子：
5.4
作者：
Bilenki, L;Yang, J;Yang, X
通讯作者：
Yang, X
影响因子：
4.6
作者：
Holt, P. G.;van den Biggelaar, A. H. J.
通讯作者：
van den Biggelaar, A. H. J.
影响因子：
4.4
作者：
Kim, Hye Young;Pichavant, Muriel;Umetsu, Dale T.
通讯作者：
Umetsu, Dale T.
影响因子：
14.2
作者：
Boasen, J;Chisholm, D;Horner, AA
通讯作者：
Horner, AA
影响因子：
30.5
作者：
Kinjo, Yuki;Tupin, Emmanuel;Kronenberg, Mitchell
通讯作者：
Kronenberg, Mitchell