Classification of intrinsically disordered regions and proteins.
Classification of intrinsically disordered regions and proteins.
复制标题
DOI：
10.1021/cr400525m
复制
发表时间：
2014-07-09
期刊：
影响因子：
62.1
通讯作者：
Babu, M. Madan
中科院分区：
文献类型：
--
作者：
van der Lee, Robin;Buljan, Marija;Lang, Benjamin;Weatheritt, Robert J.;Daughdrill, Gary W.;Dunker, A. Keith;Fuxreiter, Monika;Gough, Julian;Gsponer, Joerg;Jones, David T.;Kim, Philip M.;Kriwacki, Richard W.;Oldfield, Christopher J.;Pappu, Rohit V.;Tompa, Peter;Uversky, Vladimir N.;Wright, Peter E.;Babu, M. Madan
在过去的十年中，我们观察到描述来自各种生物体的蛋白质序列的信息量大幅增加。1,2这可能反映了序列空间的多样性，也可能反映了函数空间的多样性，3很大一部分序列缺乏任何有用的函数注释。这些序列通常被注释为假定的或假设的蛋白质，并且大多数它们的功能仍然未知。6,7关于蛋白质潜在功能的建议，主要是分子功能，通常来自对其序列的计算分析。例如，同源性检测允许将信息从具有良好特征的蛋白质片段转移到具有相似序列但缺乏分子功能注释的片段。8−10功能的其他方面，如蛋白质参与的生物过程，可能来自遗传和疾病关联研究、表达和相互作用网络数据以及研究基因组背景的比较基因组学方法。11−17对未注释和未表征的蛋白质片段的表征有望导致新功能的发现，并为现有的生物过程提供重要的见解。此外，它还可能为尚未完全了解的疾病的分子机制提供新的线索。因此，可能存在未表征的蛋白质片段
Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from a variety of organisms. 1, 2 While this may reflect the diversity in sequence space, and possibly also in function space, 3 a large proportion of the sequences lacks any useful function annotation. 4, 5 Often these sequences are annotated as putative or hypothetical proteins, and for the majority their functions still remain unknown. 6, 7 Suggestions about potential protein function, primarily molecular function, often come from computational analysis of their sequences. For instance, homology detection allows for the transfer of information from well-characterized protein segments to those with similar sequences that lack annotation of molecular function. 8− 10 Other aspects of function, such as the biological processes proteins participate in, may come from genetic-and diseaseassociation studies, expression and interaction network data, and comparative genomics approaches that investigate genomic context. 11− 17 Characterization of unannotated and uncharacterized protein segments is expected to lead to the discovery of novel functions as well as provide important insights into existing biological processes. In addition, it is likely to shed new light on molecular mechanisms of diseases that are not yet fully understood. Thus, uncharacterized protein segments are likely
登录
查看更多内容
影响因子：
13.8
作者：
Bardwell JC;Jakob U
通讯作者：
Jakob U
影响因子：
5.6
作者：
Aravind, L;Koonin, EV
通讯作者：
Koonin, EV
影响因子：
7.2
作者：
Balagopalan, Lakshmi;Coussens, Nathan P.;Sommers, Connie L.
通讯作者：
Sommers, Connie L.
影响因子：
4
作者：
Asher, Gad;Reuven, Nina;Shaul, Yosef
通讯作者：
Shaul, Yosef
影响因子：
10.5
作者：
Asher, G;Tsvetkov, P;Shaul, Y
通讯作者：
Shaul, Y