Salivary Exosomes in Health and Disease: Future Prospects in the Eye.

Salivary Exosomes in Health and Disease: Future Prospects in the Eye.
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DOI:
10.3390/ijms24076363
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发表时间:
2023-03-28
影响因子:
5.6
通讯作者:
Karamichos, Dimitrios
Karamichos, Dimitrios
中科院分区:
生物学2区
文献类型:
--
作者:
Liu, Angela;Hefley, Brenna;Escandon, Paulina;Nicholas, Sarah E.;Karamichos, Dimitrios

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外泌体是一组囊泡,其将DNA、RNA、蛋白质和脂质包装并运输至受体细胞。它们可以来源于血液、唾液、尿液和/或其他生物组织。它们对几种疾病的影响,如神经退行性疾病、自身免疫性疾病和眼部疾病,已有报道,但尚未完全阐明。来源于唾液的外泌体研究较少,但由于其可获得性和易于收集,与来自其他来源的外泌体相比具有显着优势。因此,它们在疾病的病理生理学中的作用在很大程度上是未知的。在眼部疾病的背景下,唾液外泌体一直未得到充分利用,因此在文献中造成了巨大的空白。本文综述了外泌体在全身性和眼部疾病中的研究现状,并强调了唾液外泌体作为未来眼部治疗载体的作用和潜力。
Exosomes are a group of vesicles that package and transport DNA, RNA, proteins, and lipids to recipient cells. They can be derived from blood, saliva, urine, and/or other biological tissues. Their impact on several diseases, such as neurodegenerative, autoimmune, and ocular diseases, have been reported, but not fully unraveled. The exosomes that are derived from saliva are less studied, but offer significant advantages over exosomes from other sources, due to their accessibility and ease of collection. Thus, their role in the pathophysiology of diseases is largely unknown. In the context of ocular diseases, salivary exosomes have been under-utilized, thus creating an enormous gap in the literature. The current review discusses the state of exosomes research on systemic and ocular diseases and highlights the role and potential of salivary exosomes as future ocular therapeutic vehicles.
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