High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting.
High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting.
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DOI：
10.1371/journal.pone.0164016
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Bergh A
中科院分区：
文献类型：
--
作者：
Hammarsten P;Dahl Scherdin T;Hägglöf C;Andersson P;Wikström P;Stattin P;Egevad L;Granfors T;Bergh A
在本研究中，我们研究了Caveolin-1在非恶性和恶性前列腺组织中的表达是否是观察等待治疗前列腺癌患者预后的潜在预后标志物。对395例诊断为前列腺癌的患者经尿道前列腺切除术获得的前列腺组织进行了小窝蛋白-1的测定。大多数患者（n = 298）在诊断后进行观察等待。用抗Caveolin-1抗体对恶性和非恶性前列腺组织构建的组织微阵列进行染色。对染色模式进行评分，并与临床病理参数和预后相关。对非恶性组织前列腺间质和Gleason 3、4肿瘤间质进行Cav-1的显微解剖和qRT-PCR分析。Cav-1 RNA在非恶性组织中表达最高，在癌症进展过程中表达降低。在前列腺癌患者中，肿瘤基质中高表达的Caveolin-1与较长的肿瘤特异性生存相关。在Cox回归模型中，当Gleason评分和局部肿瘤分期与Caveolin-1结合使用时，这种相关性仍然显著。前列腺肿瘤中高间质小窝蛋白-1免疫反应性与观察等待治疗前列腺癌患者的良好预后相关。Caveolin-1可能成为前列腺癌患者的一个有用的预后标志物，是积极监测的潜在候选者。
In the present study we have investigated whether Caveolin-1 expression in non-malignant and malignant prostate tissue is a potential prognostic marker for outcome in prostate cancer patients managed by watchful waiting. Caveolin-1 was measured in prostate tissues obtained through transurethral resection of the prostate from 395 patients diagnosed with prostate cancer. The majority of the patients (n = 298) were followed by watchful waiting after diagnosis. Tissue microarrays constructed from malignant and non-malignant prostate tissue were stained with an antibody against Caveolin-1. The staining pattern was scored and related to clinicopathologic parameters and outcome. Microdissection and qRT-PCR analysis of Cav-1 was done of the prostate stroma from non-malignant tissue and stroma from Gleason 3 and 4 tumors. Cav-1 RNA expression was highest in non-malignant tissue and decreased during cancer progression. High expression of Caveolin-1 in tumor stroma was associated with significantly longer cancer specific survival in prostate cancer patients. This association remained significant when Gleason score and local tumor stage were combined with Caveolin-1 in a Cox regression model. High stromal Caveolin-1 immunoreactivity in prostate tumors is associated with a favourable prognosis in prostate cancer patients managed by watchful waiting. Caveolin-1 could possibly become a useful prognostic marker for prostate cancer patients that are potential candidates for active surveillance.
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影响因子：
3.7
作者：
Hägglöf C;Hammarsten P;Josefsson A;Stattin P;Paulsson J;Bergh A;Ostman A
通讯作者：
Ostman A
影响因子：
8
作者：
Li, X.;Placencio, V.;Iturregui, J. M.;Uwamariya, C.;Sharif-Afshar, A-R;Koyama, T.;Hayward, S. W.;Bhowmick, N. A.
通讯作者：
Bhowmick, N. A.
影响因子：
3.7
作者：
Hammarsten, Peter;Cipriano, Mariateresa;Fowler, Christopher J.
通讯作者：
Fowler, Christopher J.
影响因子：
11.2
作者：
Franco OE;Jiang M;Strand DW;Peacock J;Fernandez S;Jackson RS 2nd;Revelo MP;Bhowmick NA;Hayward SW
通讯作者：
Hayward SW
DOI：
10.1517/17530059.2011.540009
发表时间：
2011-01-01
期刊：
Expert opinion on medical diagnostics
影响因子：
--
作者：
Halin, Sofia;Hammarsten, Peter;Bergh, Anders
通讯作者：
Bergh, Anders