Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology.
Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology.
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DOI：
10.1016/j.pscychresns.2008.05.005
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发表时间：
2009-04-30
影响因子：
2.3
通讯作者：
Morey, Rajendra A.
中科院分区：
文献类型：
--
作者：
Hayes, Jasmeet Pannu;LaBar, Kevin S.;Petty, Christopher M.;McCarthy, Gregory;Morey, Rajendra A.
创伤后应激障碍（PTSD）的信息加工模型表明，PTSD的特点是优先分配的注意资源，潜在的威胁刺激。然而，很少有研究探讨与PTSD相关的注意力和情绪的神经模式。在本研究中，患有创伤后应激障碍的退伍军人在接受功能性磁共振成像（fMRI）时进行了一项情绪古怪的任务。根据戴维森创伤量表（DTS）的评分，退伍军人被分为高症状组或低症状组。参与者区分不频繁的目标刺激（圆圈）频繁的标准（正方形），而情绪和中性干扰不频繁和不规则。结果显示，参与者与更大的创伤后应激障碍表现出增强的神经活动，在腹侧边缘和背侧区域的情绪刺激和衰减的活动，在背外侧前额叶和顶叶区域的注意力目标。在扣带回前部，PTSD症状较少的参与者对注意力和情绪刺激表现出相同的反应，而高症状组对负面情绪刺激表现出更大的激活。两者合计，结果表明，高反应腹侧边缘活动加上改变背侧注意和前扣带功能可能是注意力偏差的PTSD的神经标志物。
Information processing models of posttraumatic stress disorder (PTSD) suggest that PTSD is characterized by preferential allocation of attentional resources to potentially threatening stimuli. However, few studies have examined the neural pattern underlying attention and emotion in association with PTSD symptomatology. In the present study, combat veterans with PTSD symptomatology engaged in an emotional oddball task while undergoing functional magnetic resonance imaging (fMRI). Veterans were classified into a high or low symptomatology group based on their scores on the Davidson Trauma Scale (DTS). Participants discriminated infrequent target stimuli (circles) from frequent standards (squares) while emotional and neutral distractors were presented infrequently and irregularly. Results revealed that participants with greater PTSD symptomatology showed enhanced neural activity in ventral-limbic and dorsal regions for emotional stimuli and attenuated activity in dorsolateral prefrontal and parietal regions for attention targets. In the anterior cingulate gyrus, participants with fewer PTSD symptoms showed equivalent responses to attentional and emotional stimuli while the high symptom group showed greater activation for negative emotional stimuli. Taken together, the results suggest that hyperresponsive ventral-limbic activity coupled with altered dorsal-attention and anterior cingulate function may be a neural marker of attention bias in PTSD.
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