Restraint stress attenuates nicotine's locomotor stimulant but not discriminative stimulus effects in rats.
Restraint stress attenuates nicotine's locomotor stimulant but not discriminative stimulus effects in rats.
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DOI：
10.1016/j.pbb.2014.05.012
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发表时间：
2014-09
影响因子：
3.6
通讯作者：
LeSage, Mark G.
中科院分区：
文献类型：
--
作者：
Harris, Andrew C.;Mattson, Christina;Shelley, David;LeSage, Mark G.
压力增强了几种成瘾药物的运动刺激和辨别刺激效应（例如，然而，在这些行为模型中，压力和尼古丁效应之间的相互作用还没有很好地建立起来。为此，目前的研究探讨了束缚应激对尼古丁诱导的大鼠自发活动和尼古丁辨别的影响。我们使用了一种新的方法，其中压力和尼古丁给药同时发生（即，同时暴露）以模拟压力对正在进行的烟草使用的影响，以及在压力和尼古丁施用之间施加延迟的更传统的方法（即，顺序曝光）。同时暴露于应激降低了每日注射尼古丁（0.4 mg/kg，s.c.）诱导的运动致敏率。较低剂量的尼古丁（0.1 mg/kg，s.c.）对活动产生适度的影响，通常不受同时暴露于压力的影响。连续暴露于应激和尼古丁（0.4 mg/kg，s.c.）轻度抑制尼古丁诱导的活动，但不影响自发敏化率。无论是同时或连续暴露于压力的尼古丁（0.01 - 0.2毫克/公斤，皮下注射）的歧视性刺激效应的影响。这些数据表明，束缚应激降低了尼古丁的运动刺激作用，特别是当应激和尼古丁暴露同时发生时，但不影响尼古丁辨别。这些发现与压力增强其他药物在这些模型中的作用的能力形成对比。这项研究还表明，研究同时压力暴露对药物作用的影响可能有助于理解压力在成瘾中的作用。
Stress enhances the locomotor stimulant and discriminative stimulus effects of several addictive drugs (e.g., morphine) in rodents, yet interactions between stress and nicotine’s effects in these behavioral models have not been well established. To this end, the current studies examined the effects of restraint stress on nicotine-induced locomotor activity and nicotine discrimination in rats. We used a novel approach in which onset of stress and nicotine administration occurred concurrently (i.e., simultaneous exposure) to simulate effects of stress on ongoing tobacco use, as well as a more traditional approach in which a delay was imposed between stress and nicotine administration (i.e., sequential exposure). Simultaneous exposure to stress reduced the rate of locomotor sensitization induced by daily injections of nicotine (0.4 mg/kg, s.c.). A lower dose of nicotine (0.1 mg/kg, s.c.) produced modest effects on activity that were generally unaffected by simultaneous exposure to stress. Sequential exposure to stress and nicotine (0.4 mg/kg, s.c.) slightly suppressed nicotine-induced activity, but did not influence rate of locomotor sensitization. Neither simultaneous nor sequential exposure to stress influenced the discriminative stimulus effects of nicotine (0.01 – 0.2 mg/kg, s.c.). These data show that restraint stress reduces nicotine’s locomotor stimulant effects, particularly when onset of stress and nicotine exposure occurs simultaneously, but does not influence nicotine discrimination. These findings contrast with the ability of stress to enhance the effects of other drugs in these models. This study also suggests that studying the influence of simultaneous stress exposure on drug effects may be useful for understanding the role of stress in addiction.
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影响因子：
2.9
作者：
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通讯作者：
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作者：
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作者：
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