Chromatin-remodeling factor OsINO80 is involved in regulation of gibberellin biosynthesis and is crucial for rice plant growth and development.
Chromatin-remodeling factor OsINO80 is involved in regulation of gibberellin biosynthesis and is crucial for rice plant growth and development.
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染色质重塑因子 OsINO80 参与赤霉素生物合成的调节，对水稻植物的生长和发育至关重要。
DOI：
10.1111/jipb.12603
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发表时间：
2018-02
期刊：
影响因子：
--
通讯作者：
Dong A
中科院分区：
文献类型：
--
作者：
Li C;Liu Y;Shen WH;Yu Y;Dong A
The phytohormone gibberellin (GA) plays essential roles in plant growth and development. Here, we report that OsINO80, a conserved ATP-dependent chromatin-remodeling factor in rice (Oryza sativa), functions in both GA biosynthesis and diverse biological processes. OsINO80-knockdown mutants, derived from either T-DNA insertion or RNA interference, display typical GA-deficient phenotypes, including dwarfism, reduced cell length, late flowering, retarded seed germination and impaired reproductive development. Consistently, transcriptome analyses reveal that OsINO80 knockdown results in downregulation by more than two-fold of over 1,000 genes, including the GA biosynthesis genes CPS1 and GA3ox2, and the dwarf phenotype of OsINO80-knockdown mutants can be rescued by the application of exogenous GA3. Chromatin immunoprecipitation (ChIP) experiments show that OsINO80 directly binds to the chromatin of CPS1 and GA3ox2 loci. Biochemical assays establish that OsINO80 specially interacts with histone variant H2A.Z and the H2A.Z enrichments at CPS1 and GA3ox2 are decreased in OsINO80-knockdown mutants. Thus, our study identified a rice chromatin-remodeling factor, OsINO80, and demonstrated that OsINO80 is involved in regulation of the GA biosynthesis pathway and plays critical functions for many aspects of rice plant growth and development.
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DOI：
10.1111/tpj.12840
发表时间：
2015-05
期刊：
The Plant journal : for cell and molecular biology
影响因子：
--
作者：
Chi Zhang;Lin Cao;L. Rong;Zengxuan An;Wangbin Zhou;Jinbiao Ma;W. Shen;Yan Zhu;A. Dong
通讯作者：
Chi Zhang;Lin Cao;L. Rong;Zengxuan An;Wangbin Zhou;Jinbiao Ma;W. Shen;Yan Zhu;A. Dong
影响因子：
46.9
作者：
Trapnell C;Williams BA;Pertea G;Mortazavi A;Kwan G;van Baren MJ;Salzberg SL;Wold BJ;Pachter L
通讯作者：
Pachter L
组蛋白标记阅读器 MRG1/2 通过与 CONSTANS 相互作用调节 FT 表达来调节拟南芥开花
影响因子：
4.5
作者：
Bu Z;Yu Y;Li Z;Liu Y;Jiang W;Huang Y;Dong AW
通讯作者：
Dong AW
DOI：
10.1002/j.1460-2075.1987.tb02730.x
发表时间：
1987-12
期刊：
The EMBO Journal
影响因子：
--
作者：
R. Jefferson;T. Kavanagh;M. Bevan
通讯作者：
R. Jefferson;T. Kavanagh;M. Bevan
影响因子：
4.6
作者：
Choi, Kyuha;Park, Chulmin;Lee, Ilha
通讯作者：
Lee, Ilha