Synthesis, physicochemical characterization, and cytocompatibility of bioresorbable, dual-gelling injectable hydrogels.
Synthesis, physicochemical characterization, and cytocompatibility of bioresorbable, dual-gelling injectable hydrogels.
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DOI：
10.1021/bm401413c
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发表时间：
2014-01-13
影响因子：
6.2
通讯作者：
Mikos, Antonios G.
中科院分区：
文献类型：
--
作者：
Vo, Tiffany N.;Ekenseair, Adam K.;Kasper, F. Kurtis;Mikos, Antonios G.
Injectable, dual-gelling hydrogels were successfully developed through the combination of physical thermogellation at 37°C and favorable amine:epoxy chemical crosslinking. Poly(N-isopropylacrylamide)-based thermogelling macromers with a hydrolyzable lactone ring and epoxy pendant groups, and a biodegradable diamine-functionalized polyamidoamine crosslinker were synthesized, characterized, and combined to produce non-syneresing and bioresorbable hydrogels. Differential scanning calorimetry and oscillatory rheometry demonstrated the rapid and dual-gelling nature of the hydrogel formation. The post-gelation dimensional stability, swelling, and mechanical behavior of the hydrogel system were shown to be easily tuned at the synthesis and formulation stages. The leachable products were found to be cytocompatible at all conditions, while the degradation products demonstrated a dose- and time-dependent response due to solution osmolality. Preliminary encapsulation studies showed MSC viability could be maintained for 7 days. The results suggest that injectable, thermally and chemically crosslinkable hydrogels are promising alternatives to prefabricated biomaterials for tissue engineering applications, particularly for cell delivery.
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影响因子：
16.1
作者：
Ekenseair, Adam K.;Kasper, F. Kurtis;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
3.6
作者：
Cui, Zhanwu;Lee, Bae Hoon;Vernon, Brent L.
通讯作者：
Vernon, Brent L.
影响因子：
14
作者：
Klouda, Leda;Hacker, Michael C.;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
6.2
作者：
Ekenseair, Adam K.;Boere, Kristel W. M.;Tzouanas, Stephanie N.;Vo, Tiffany N.;Kasper, F. Kurtis;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
5.5
作者：
MIJOVIC, J;FISHBAIN, A;WIJAYA, J
通讯作者：
WIJAYA, J