Synthesis and characterization of thermally and chemically gelling injectable hydrogels for tissue engineering.
Synthesis and characterization of thermally and chemically gelling injectable hydrogels for tissue engineering.
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DOI：
10.1021/bm300429e
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发表时间：
2012-06-11
影响因子：
6.2
通讯作者：
Mikos, Antonios G.
中科院分区：
文献类型：
--
作者：
Ekenseair, Adam K.;Boere, Kristel W. M.;Tzouanas, Stephanie N.;Vo, Tiffany N.;Kasper, F. Kurtis;Mikos, Antonios G.
新型可注射水凝胶在制备和温度升高至37℃时通过物理和化学双重凝胶机制固化。本文合成了一种热胶聚n -异丙基丙烯酰胺基环氧环悬垂高分子聚合物和一种可水解降解的聚酰胺胺基二胺交联剂，对其进行了表征，并将其结合在一起制备了原位形成的水凝胶结构。通过环氧胺反应形成的网络被证明是快速和容易的，并且亲水性聚酰胺胺交联剂逐渐加入到水凝胶中被证明可以缓解热凝胶材料经常出现的问题，即在形成后发生显着的凝胶协同作用。结果表明，由于其组分材料的合成通用性和有益的水凝胶凝胶动力学和稳定性，这种新型可注射水凝胶可能是组织工程应用的有吸引力的底物。
Novel, injectable hydrogels were developed that solidify through a dual-gelation, physical and chemical, mechanism upon preparation and elevation of temperature to 37°C. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant epoxy rings and a hydrolytically-degradable polyamidoamine-based diamine crosslinker were synthesized, characterized, and combined to produce in situ forming hydrogel constructs. Network formation through the epoxy-amine reaction was shown to be rapid and facile, and the progressive incorporation of the hydrophilic polyamidoamine crosslinker into the hydrogel was shown to mitigate the often problematic tendency of thermogelling materials to undergo significant post-formation gel syneresis. The results suggest that this novel class of injectable hydrogels may be attractive substrates for tissue engineering applications due to the synthetic versatility of the component materials and beneficial hydrogel gelation kinetics and stability.
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影响因子：
6.2
作者：
Kretlow, James D.;Hacker, Michael C.;Klouda, Leda;Ma, Brandy B.;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
DOI：
10.1081/ma-200050470
发表时间：
2005-03-01
期刊：
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY
影响因子：
--
作者：
Dey, RK;Ray, AR
通讯作者：
Ray, AR
影响因子：
6.2
作者：
Robb, Stephanie A.;Lee, Bae Hoon;Vernon, Brent L.
通讯作者：
Vernon, Brent L.
影响因子：
3.6
作者：
Cui, Zhanwu;Lee, Bae Hoon;Vernon, Brent L.
通讯作者：
Vernon, Brent L.
影响因子：
14
作者：
Klouda, Leda;Hacker, Michael C.;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.