Effects of repeated binge intake of the pyrovalerone cathinone derivative 3,4-methylenedioxypyrovalerone on prefrontal cytokine levels in rats - a preliminary study.
Effects of repeated binge intake of the pyrovalerone cathinone derivative 3,4-methylenedioxypyrovalerone on prefrontal cytokine levels in rats - a preliminary study.
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DOI：
10.3389/fnbeh.2023.1275968
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发表时间：
2023
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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滥用药物会激活大脑成瘾相关区域的神经免疫信号，包括调节执行控制、注意力和行为抑制的前额叶皮层（PFC）。传统的精神兴奋剂，包括甲基苯丙胺和可卡因，已知会诱导PFC炎症，但合成卡西酮衍生物的影响在很大程度上是未知的。在这项研究中，我们检查了重复暴食式摄入吡咯戊酮卡西酮衍生物3，4-亚甲基二氧基吡咯戊酮（MDPV）改变PFC中细胞因子谱的能力。（0.05 mg/kg/输注）或生理盐水作为对照，包括三个96小时的药物获取期，中间穿插72小时的强制禁欲。停药3周后，使用抗体阵列评估PFC细胞因子水平。采用无监督聚类和回归分析工具CytoMod，确定了与MDPV摄入相关的协同信号细胞因子的单个模块，而不考虑性别。至于特定的细胞因子，MDPV摄入量与VCAM-1/CD 106的PFC水平呈正相关，与Flt-3配体水平呈负相关。这些研究结果表明，长期MDPV摄入导致PFC细胞因子水平的变化，持续到禁欲，但是，这些变化的功能分支仍有待充分阐明。
Drugs of abuse activate neuroimmune signaling in addiction-related regions of the brain, including the prefrontal cortex (PFC) which mediates executive control, attention, and behavioral inhibition. Traditional psychostimulants including methamphetamine and cocaine are known to induce PFC inflammation, yet the effects of synthetic cathinone derivatives are largely unexplored. In this study, we examined the ability of repeated binge-like intake of the pyrovalerone cathinone derivative 3,4-methylenedioxypyrovalerone (MDPV) to alter cytokine profiles in the PFC. Male and female rats were allowed to intravenously self-administer MDPV (0.05 mg/kg/infusion) or saline as a control under conditions of prolonged binge-like access, consisting of three 96 h periods of drug access interspersed with 72 h of forced abstinence. Three weeks following cessation of drug availability, PFC cytokine levels were assessed using antibody arrays. Employing the unsupervised clustering and regression analysis tool CytoMod, a single module of co-signaling cytokines associated with MDPV intake regardless of sex was identified. With regards to specific cytokines, MDPV intake was positively associated with PFC levels of VCAM-1/CD106 and negatively associated with levels of Flt-3 ligand. These findings indicate that prolonged MDPV intake causes changes in PFC cytokine levels that persist into abstinence; however, the functional ramifications of these changes remain to be fully elucidated.
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影响因子：
4.3
作者：
Namba MD;Leyrer-Jackson JM;Nagy EK;Olive MF;Neisewander JL
通讯作者：
Neisewander JL
影响因子：
3.4
作者：
通讯作者：
--
影响因子：
1.6
作者：
Gannon BM;Rice KC;Collins GT
通讯作者：
Collins GT
影响因子：
10.6
作者：
Seney ML;Kim SM;Glausier JR;Hildebrand MA;Xue X;Zong W;Wang J;Shelton MA;Phan BN;Srinivasan C;Pfenning AR;Tseng GC;Lewis DA;Freyberg Z;Logan RW
通讯作者：
Logan RW
影响因子：
7.3
作者：
Cohen, Liel;Fiore-Gartland, Andrew;Hertz, Tomer
通讯作者：
Hertz, Tomer