Long-term impact of respiratory viral infection after pediatric lung transplantation.
Long-term impact of respiratory viral infection after pediatric lung transplantation.
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DOI：
10.1111/j.1399-3046.2010.01296.x
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发表时间：
2010-05
影响因子：
1.3
通讯作者：
Danziger-Isakov LA
中科院分区：
文献类型：
--
作者：
Liu M;Mallory GB;Schecter MG;Worley S;Arrigain S;Robertson J;Elidemir O;Danziger-Isakov LA
为了评估流行病学并探讨呼吸道病毒感染（RVI）对儿童肺移植术后慢性同种异体排斥反应的影响，对2002 - 2007年儿童肺移植受者进行了回顾性研究。分别使用Wilcoxon秩和检验和Fisher精确检验评估RVI与连续和分类危险因素之间的关系。使用Cox比例风险模型评估危险因素与结果之间的关系。55名受试者平均随访674天（范围14-1790）。28例（51%）在移植后144天（平均246天，范围1-1276天）发生51次RVI；41%的感染在90天内被诊断出来。25例患者出现39例下呼吸道感染，8例患者出现11例上呼吸道感染（URI）。检出的微生物包括鼻病毒（n=14）、腺病毒（n=10）、副流感病毒（n=10）、流感病毒（n=5）和呼吸道合胞病毒（n=4）。3例患者继发于RVI死亡（2例腺病毒，1例RSV）。年龄较小和既往CMV感染是RVI的危险因素（HR 2.4, 95% CI分别为1.1-5.3和17.0;3.0-96.2）。在研究期间，RVI与慢性同种异体移植排斥反应的发生（P=0.25）或死亡无关。RVI发生在大多数儿童肺移植受者中，但与死亡率或慢性同种异体移植排斥反应无关。
To evaluate the epidemiology and to investigate the impact of respiratory viral infections (RVI) on chronic allograft rejection after pediatric lung transplantation, a retrospective study of pediatric lung transplant recipients from 2002 to 2007 was conducted. Association between RVI and continuous and categorical risk factors was assessed using Wilcoxon rank-sum tests and Fisher’s exact tests, respectively. Association between risk factors and outcomes were assessed using Cox proportional hazards models. Fifty-five subjects were followed for a mean of 674 days (range 14–1790). Twenty-eight (51%) developed 51 RVI at a median of 144 days posttransplant (mean 246; range 1–1276); 41% of infections were diagnosed within 90 days. 25 subjects developed 39 lower respiratory infections, and eight subjects had 11 upper respiratory infections (URI). Organisms recovered included rhinovirus(n=14), adenovirus(n=10), parainfluenza(n=10), influenza(n=5) and RSV(n=4). Three subjects expired secondary to their RVI (2 adenovirus, 1 RSV). Younger age and prior CMV infection were risks for RVI (HR 2.4 95% CI 1.1–5.3 and 17.0; 3.0–96.2, respectively). RVI was not associated with the development of chronic allograft rejection (P=0.25) or death during the study period. RVI occur in the majority of pediatric lung transplant recipients, but were not associated with mortality or chronic allograft rejection.
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影响因子：
11.8
作者：
Ascioglu, S;Rex, JH;Walsh, TJ
通讯作者：
Walsh, TJ
影响因子：
8.8
作者：
Kumar, D;Erdman, D;Humar, A
通讯作者：
Humar, A
影响因子：
--
作者：
KRAMER, MR;MARSHALL, SE;THEODORE, J
通讯作者：
THEODORE, J
影响因子：
6.2
作者：
Westall, GP;Michaelides, A;Kotsimbos, TC
通讯作者：
Kotsimbos, TC
DOI：
10.1016/s0022-5223(95)70419-1
发表时间：
1995-01-01
影响因子：
6
作者：
BANDO, K;PARADIS, IL;GRIFFITH, BP
通讯作者：
GRIFFITH, BP