Relation of Patent Foramen Ovale to Acute Mountain Sickness.
Relation of Patent Foramen Ovale to Acute Mountain Sickness.
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卵圆孔未闭与急性高山病的关系。
DOI：
10.1016/j.amjcard.2019.03.030
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Tobis,JonathanM
中科院分区：
文献类型：
--
作者：
West,BrianH;Fleming,RubineGevorgyan;AlHemyari,Bashar;Banankhah,Pooya;Meyer,Kenneth;Rozier,LeslieH;Murphy,LindaS;Coluzzi,AlexandraC;Rusheen,JoshuaL;Kumar,Preetham;Elashoff,David;Tobis,JonathanM
超过50%的快速上升到极端海拔的患者会出现各种被称为急性高原反应(AMS)的症状，这种症状很少会危及生命。目前尚不清楚为什么一些患者比其他患者更容易患AMS。我们的目标是确定卵圆孔未闭(PFO)是否是AMS的危险因素。在加利福尼亚州约翰缪尔步道上徒步旅行到海拔10,000英尺(∼3,000米)以上的受试者被招募。参与者完成了一份问卷，并进行了关于AMS状态的两名医生的裁决。采用经颅多谱勒搅拌生理盐水对比剂注射来评估PFO的存在或不存在。主要结果是AMS的发展。从2016年到2018年，137名徒步旅行者被招募到这项研究中。有AM的徒步旅行者中有15人(63%)比没有AM的徒步旅行者中有44人(39%)有更高的PFO患病率；p = 0.034。在多变量模型中，PFO的存在显著增加了发生急性多发性硬化的风险：优势比为4.15，95%可信区间为1.14至15.05；p = 为0.030。总而言之，与没有PFO的徒步旅行者相比，患有PFO的徒步旅行者发生AMS的风险显著更高。对于计划前往高海拔地区的患者，临床医生应将PFO视为一个危险因素。
Over 50% of patients who rapidly ascend to extreme altitudes develop various symptoms known as acute mountain sickness (AMS), which rarely can be life threatening. It is unclear why some patients are more susceptible to AMS than others. Our objective was to determine whether patent foramen ovale (PFO) is a risk factor for AMS. Subjects who had hiked to altitudes above 10,000′ (∼3,000 meters) on the John Muir Trail in California were recruited. Participants completed a questionnaire and 2-physician adjudication was performed in regard to AMS status. A transcranial Doppler with agitated saline contrast injection was performed to evaluate the presence or absence of PFO. The primary outcome was the development of AMS. From 2016 to 2018, 137 hikers were recruited into the study. There was a higher prevalence of PFO in hikers with AMS 15 of 24 (63%) compared with hikers without AMS 44 of 113 (39%); p = 0.034. In the multivariate model, the presence of a PFO significantly increased the risk for developing AMS: odds ratio 4.15, 95% confidence intervals 1.14 to 15.05; p = 0.030. In conclusion, hikers with a PFO had significantly higher risk of developing AMS relative to hikers without a PFO. Clinicians should consider PFO a risk factor in patients who plan to hike to high altitudes.
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DOI：
10.2147/opth.s30999
发表时间：
2012
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Mojadidi MK;Khessali H;Gevorgyan R;Levinson RD;Tobis JM
通讯作者：
Tobis JM
影响因子：
158.5
作者：
JOHNSON, TS;ROCK, PB
通讯作者：
ROCK, PB
影响因子：
2.4
作者：
Lao, Annabelle Y.;Sharma, Vijay K.;Alexandrov, Andrei V.
通讯作者：
Alexandrov, Andrei V.
影响因子：
14
作者：
Mojadidi, M. Khalid;Roberts, Scott C.;Tobis, Jonathan M.
通讯作者：
Tobis, Jonathan M.
影响因子：
2.4
作者：
D. Wagner;J. Fargo;D. Parker;Kevin Tatsugawa;T. A. Young
通讯作者：
T. A. Young