Concurrent TMS-fMRI reveals dynamic interhemispheric influences of the right parietal cortex during exogenously cued visuospatial attention.

Concurrent TMS-fMRI reveals dynamic interhemispheric influences of the right parietal cortex during exogenously cued visuospatial attention.
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DOI:
10.1111/j.1460-9568.2010.07580.x
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发表时间:
2011-03
期刊:
The European journal of neuroscience
影响因子:
--
通讯作者:
Chambers CD
Chambers CD
中科院分区:
其他
文献类型:
--
作者:
Heinen K;Ruff CC;Bjoertomt O;Schenkluhn B;Bestmann S;Blankenburg F;Driver J;Chambers CD

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我们同时使用经颅磁刺激和功能磁共振成像(TMS-fMRI)在人类的视觉空间线索范式,研究的因果作用的右角回(AG)的注意力控制的来源。我们的研究结果表明,TMS在正确的AG(高与低强度)调制神经反应的interhemispherically,在动态变化的方式与当前的注意力状况。这种TMS的行为影响不仅取决于目标半野,但也对外源性线索的有效性,促进空间重定向到无效提示的右视觉目标。在神经水平上,右侧AG TMS在左侧AG和左侧视网膜皮层(包括V1区)具有相应的半球间效应。我们的结论是,隐蔽的视觉空间注意力的方向可以涉及动态的相互作用之间的权利AG和远程相互连接的区域的相对的左半球,而我们的研究结果还表明,右AG可以影响视网膜视皮层的反应。
We used concurrent transcranial magnetic stimulation and functional MRI (TMS-fMRI) during a visuospatial cueing paradigm in humans, to study the causal role of the right angular gyrus (AG) as a source of attentional control. Our findings show that TMS over the right AG (high vs. low intensity) modulates neural responses interhemispherically, in a manner that varies dynamically with the current attentional condition. The behavioural impact of such TMS depended not only on the target hemifield but also on exogenous cue validity, facilitating spatial reorienting to invalidly cued right visual targets. On a neural level, right AG TMS had corresponding interhemispheric effects in the left AG and left retinotopic cortex, including area V1. We conclude that the direction of covert visuospatial attention can involve dynamic interplay between the right AG and remote interconnected regions of the opposite left hemisphere, whereas our findings also suggest that the right AG can influence responses in the retinotopic visual cortex.
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