Inflammation, brain connectivity, and neuromodulation in post-traumatic headache.
Inflammation, brain connectivity, and neuromodulation in post-traumatic headache.
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创伤后头痛的炎症、脑连通性和神经调节。
DOI：
10.1016/j.bbih.2024.100723
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发表时间：
2024-02
期刊：
影响因子：
--
通讯作者：
Chung, Man- Kyo
中科院分区：
文献类型：
--
作者：
Fiorin, Fernando da Silva;Santo, Caroline Cunha do Espirito;Silva, Joyce T. Da;Chung, Man- Kyo
创伤后头痛（PTH）是一种使人衰弱的疾病，影响不同程度的创伤性脑损伤（TBI）严重程度的个体。开发有效治疗方法的困难与缺乏对脑损伤后脑功能的复杂机制和神经生物学变化的了解有关。临床前研究表明，三叉神经伤害性通路的外周和中枢敏化有助于PTH。虽然最近的脑成像研究发现了创伤后脑功能连接的广泛变化，但确切了解这些网络如何在损伤后促进PTH仍然是未知的。刺激外周（三叉神经或迷走神经）神经在PTH实验动物中显示出有希望的功效，可能通过减少神经炎症和神经元凋亡影响TBI诱导的病理可塑性来介导。非侵入性脑刺激，如经颅磁刺激或直流电刺激，显示出对多种慢性疼痛病症（包括PTH）的镇痛作用。更好地了解神经调节实现的镇痛机制可以定义参与甲状旁腺激素的发展、消退和管理的外周和中枢机制。外周和中枢炎症介导创伤后头痛（PTH）。轴突变性可导致PTH中结构性脑连接的丧失。不同脑区中改变的脑连接与PTH阶段相关。神经刺激减少动物模型脑损伤后的炎症损伤。不同临床病理条件下电刺激缓解疼痛。
Post-traumatic headache (PTH) is a debilitating condition that affects individuals with different levels of traumatic brain injury (TBI) severity. The difficulties in developing an effective treatment are related to a lack of understanding the complicated mechanisms and neurobiological changes in brain function after a brain injury. Preclinical studies have indicated that peripheral and central sensitization of the trigeminal nociceptive pathways contributes to PTH. While recent brain imaging studies have uncovered widespread changes in brain functional connectivity following trauma, understanding exactly how these networks contribute to PTH after injury remains unknown. Stimulation of peripheral (trigeminal or vagus) nerves show promising efficacies in PTH experimental animals, likely mediated by influencing TBI-induced pathological plasticity by decreasing neuroinflammation and neuronal apoptosis. Non-invasive brain stimulations, such as transcranial magnetic or direct current stimulations, show analgesia for multiple chronic pain conditions, including PTH. Better mechanistic understanding of analgesia achieved by neuromodulations can define peripheral and central mechanisms involved in the development, the resolution, and the management of PTH. Peripheral and central inflammation mediates post-traumatic headache (PTH). Axonal degeneration can lead to loss of structural brain connectivity in PTH. Altered brain connectivity in different brain regions is associated with PTH phases. Neurostimulation reduces inflammatory damage after brain injury in animal models. Pain relief by electrical stimulation in different clinical pathological conditions.
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