Functional Alterations in the Posterior Insula and Cerebellum in Migraine Without Aura: A Resting-State MRI Study.
Functional Alterations in the Posterior Insula and Cerebellum in Migraine Without Aura: A Resting-State MRI Study.
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无先兆偏头痛中后岛叶和小脑的功能改变：静息态 MRI 研究
DOI：
10.3389/fnbeh.2020.567588
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发表时间：
2020
影响因子：
3
通讯作者：
Dai L
中科院分区：
文献类型：
--
作者：
Ke J;Yu Y;Zhang X;Su Y;Wang X;Hu S;Dai H;Hu C;Zhao H;Dai L
背景资料：假设驱动的功能连接（FC）分析揭示了发作性偏头痛患者参与疼痛处理的区域或网络的异常功能相互作用。我们的目的是研究静息状态FC模式，发作性偏头痛相结合的数据驱动的体素的程度中心性（DC）计算和种子为基础的FC分析。方法：对39例无先兆发作性偏头痛患者和35例健康对照者进行临床和功能MRI检查。DC进行了体素分析，并在组间进行了比较，并使用基于种子的方法进一步检查了DC差异区域的FC。结果如下：与对照组相比，偏头痛组在右后颅窝和左颅窝的DC分别增加和减少。基于种子的FC分析显示，偏头痛患者表现出增加的右后额叶与中央后回，辅助运动区/中央旁小叶，梭状回和颞极的连接。偏头痛患者左侧MRI显示默认模式网络（DMN）区域的FC减少，包括内侧前额叶皮层（mPFC），角回，内侧和外侧颞叶皮层。此外，疼痛强度与右侧杏仁核/海马旁回的DC呈正相关，偏头痛频率与左侧杏仁核I和mPFC之间的FC呈负相关。结论：无先兆的发作性偏头痛患者右后角FC增加，DMN内FC减少，这可能是感觉整合和疼痛认知处理障碍的基础。左mPFC连接可能是评估偏头痛频率的有用生物标志物。
Background: Hypothesis-driven functional connectivity (FC) analyses have revealed abnormal functional interaction of regions or networks involved in pain processing in episodic migraine patients. We aimed to investigate the resting-state FC patterns in episodic migraine by combining data-driven voxel-wise degree centrality (DC) calculation and seed-based FC analysis. Methods: Thirty-nine patients suffering from episodic migraine without aura and 35 healthy controls underwent clinical assessment and functional MRI. DC was analyzed voxel-wise and compared between groups, and FC of regions with DC differences were further examined using a seed-based approach. Results: Compared with the control group, the migraine group showed increased and decreased DC in the right posterior insula and left crus I, respectively. Seed-based FC analyses revealed that migraine patients demonstrated increased right posterior insula connections with the postcentral gyrus, supplementary motor area/paracentral lobule, fusiform gyrus and temporal pole. The left crus I showed decreased FC with regions of the default mode network (DMN), including the medial prefrontal cortex (mPFC), angular gyrus, medial and lateral temporal cortex in patients with migraine. Furthermore, pain intensity positively correlated with DC in the right amygdala/parahippocampal gyrus, and migraine frequency negatively correlated with FC between the left crus I and mPFC. Conclusion: Patients with episodic migraine without aura have increased FC with the right posterior insula and decreased FC within the DMN, which may underlie disturbed sensory integration and cognitive processing of pain. The left crus I-mPFC connectivity may be a useful biomarker for assessing migraine frequency.
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DOI：
10.1186/s10194-017-0782-6
发表时间：
2017-12
期刊：
The journal of headache and pain
影响因子：
--
作者：
Lo Buono V;Bonanno L;Corallo F;Pisani LR;Lo Presti R;Grugno R;Di Lorenzo G;Bramanti P;Marino S
通讯作者：
Marino S
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
9.9
作者：
Lipton, R. B.;Bigal, M. E.;Stewart, W. F.
通讯作者：
Stewart, W. F.
影响因子：
3.5
作者：
Brighina, Filippo;Palermo, Antonio;Fierro, Brigida
通讯作者：
Fierro, Brigida
DOI：
10.1016/j.jpain.2011.06.007
发表时间：
2011-12
期刊：
The journal of pain
影响因子：
--
作者：
Glass JM;Williams DA;Fernandez-Sanchez ML;Kairys A;Barjola P;Heitzeg MM;Clauw DJ;Schmidt-Wilcke T
通讯作者：
Schmidt-Wilcke T