Transient and microscale deformations and strains measured under exogenous loading by noninvasive magnetic resonance.
Transient and microscale deformations and strains measured under exogenous loading by noninvasive magnetic resonance.
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DOI：
10.1371/journal.pone.0033463
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Neu CP
中科院分区：
文献类型：
--
作者：
Chan DD;Neu CP
时空变形动力学和材料特性的表征需要非破坏性的方法来可视化材料和生物组织的力学。位移编码磁共振成像（MRI）已成为一种非侵入性和非破坏性的技术，用于量化变形和应变。然而，这些技术还不适用于广泛的材料和承重组织。在本文中，我们可视化的瞬态和内部材料变形，通过新的同步外部机械负荷与快速位移编码的MRI。我们在硅凝胶材料中实现了变形测量，空间分辨率为100 µm，时间分辨率为2.25 ms，由快速MRI采集的重复时间（TR）设置。平滑后的位移和应变精度分别为11 µm和0.1%，接近细胞长度尺度。短（1/2 TR）回波时间能够可视化人体胫股关节的原位变形，包括多种可变T2生物材料。此外，MRI采集的成像时间比以前的技术提高了五倍，为体内机械成像奠定了基础。我们的研究结果提供了一个通用的方法，非侵入性和非破坏性的测量，在高的空间和时间分辨率，广泛的承载材料和生物组织的动态力学响应。
Characterization of spatiotemporal deformation dynamics and material properties requires non-destructive methods to visualize mechanics of materials and biological tissues. Displacement-encoded magnetic resonance imaging (MRI) has emerged as a noninvasive and non-destructive technique used to quantify deformation and strains. However, the techniques are not yet applicable to a broad range of materials and load-bearing tissues. In this paper, we visualize transient and internal material deformation through the novel synchrony of external mechanical loading with rapid displacement-encoded MRI. We achieved deformation measurements in silicone gel materials with a spatial resolution of 100 µm and a temporal resolution (of 2.25 ms), set by the repetition time (TR) of the rapid MRI acquisition. Displacement and strain precisions after smoothing were 11 µm and 0.1%, respectively, approaching cellular length scales. Short (1/2 TR) echo times enabled visualization of in situ deformation in a human tibiofemoral joint, inclusive of multiple variable T2 biomaterials. Moreover, the MRI acquisitions achieved a fivefold improvement in imaging time over previous technology, setting the stage for mechanical imaging in vivo. Our results provide a general approach for noninvasive and non-destructive measurement, at high spatial and temporal resolution, of the dynamic mechanical response of a broad range of load-bearing materials and biological tissues.
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影响因子：
3.3
作者：
Lin, Alexander P.;Bennett, Eric;Wisk, Lauren E.;Gharib, Morteza;Fraser, Scott E.;Wen, Han
通讯作者：
Wen, Han
影响因子：
5.9
作者：
Scheffler, K;Lehnhardt, S
通讯作者：
Lehnhardt, S
影响因子：
3.3
作者：
Bangerter, NK;Hargreaves, BA;Nishimura, DG
通讯作者：
Nishimura, DG
影响因子：
3.3
作者：
Neu, CP;Hull, ML;Walton, JH
通讯作者：
Walton, JH
DOI：
10.1016/0020-7683(95)00240-5
发表时间：
1996-12-01
影响因子：
3.6
作者：
Geers, MGD;DeBorst, R;Brekelmans, WAM
通讯作者：
Brekelmans, WAM