On the magnetosensitivity of lipid peroxidation: two- versus three-radical dynamics.
On the magnetosensitivity of lipid peroxidation: two- versus three-radical dynamics.
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关于脂质过氧化的磁敏感性：二自由基与三自由基动力学。
DOI：
10.1039/c9cp01746a
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Sampson C
中科院分区：
文献类型：
--
作者：
Sampson C
我们提出了一个理论上的分析脂质过氧化的磁敏感性。我们重点讨论了被广泛接受的自由基对机制（RPM）和最近提出的基于电子-电子相互偶极耦合（D3M）在三自由基体系中诱导的自旋动力学的观点。我们表明，与文献中声称的相反，脂质过氧化物，自氧化过程的主要链载体，具有相关的非零超细耦合相互作用。这表明，由于转速的关系，它们的重组原则上可能是磁敏的。虽然RPM确实对解释这些体系中的磁敏感性有很长的路要走，但我们表明，即使第三个自由基远离重组自由基对，三个过氧基通过D3M同时相互作用也可以获得更大的磁场效应（MFE）。对于随机定向的三自由基体系，D3M诱导出与RPM相当的低场效应。该机制进一步使自旋动力学免受重组自由基对中存在的大交换耦合相互作用的影响，从而在与地磁场相当的磁场强度下允许比RPM预期的更大的MFE。基于这些特征，我们认为D3M可能与低场的MFE特别相关，前提是局部自由基浓度足以允许三自旋自由基相关。最终，我们的观察结果表明，mfe可能复杂地依赖于自由基浓度，并且在氧化应激条件下可能会产生更大的影响。
We present a theoretical analysis of the putative magnetosensitivity of lipid peroxidation. We focus on the widely accepted radical pair mechanism (RPM) and a recently suggested idea based on spin dynamics induced in three-radical systems by the mutual electron–electron dipolar coupling (D3M). We show that, contrary to claims in the literature, lipid peroxides, the dominant chain carriers of the autoxidation process, have associated non-zero hyperfine coupling interactions. This suggests that their recombination could, in principle, be magnetosensitive due to the RPM. While the RPM indeed goes a long way to explaining magnetosensitivity in these systems, we show that the simultaneous interaction of three peroxyl radicals via the D3M can achieve larger magnetic field effects (MFE), even if the third radical is remote from the recombining radical pair. For randomly oriented three-radical systems, the D3M induces a low-field effect comparable to that of the RPM. The mechanism furthermore immunizes the spin dynamics to the presence of large exchange coupling interactions in the recombining radical pair, thereby permitting much larger MFE at magnetic field intensities comparable to the geomagnetic field than would be expected for the RPM. Based on these characteristics, we suggest that the D3M could be particularly relevant for MFE at low fields, provided that the local radical concentration is sufficient to allow for three-spin radical correlations. Eventually, our observations suggest that MFEs could intricately depend on radical concentration and larger effects could ensue under conditions of oxidative stress.
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影响因子：
1.9
作者：
A. Kipriyanov;A. Doktorov;P. Purtov
通讯作者：
A. Kipriyanov;A. Doktorov;P. Purtov
弱永磁场对萝卜幼苗脂质过氧化的影响
影响因子：
1.4
作者：
Yu. I. Novitskii;G. Novitskaya;Yu. A. Serdyukov;T. K. Kocheshkova;D. Molokanov;M. V. Dobrovolskii
通讯作者：
M. V. Dobrovolskii
稳定磁场对脂质过氧化动力学的影响。
DOI：
10.1080/13510002.1994.11746959
发表时间：
1994
期刊：
Redox report : communications in free radical research
影响因子：
--
作者：
U. Lalo;Y. Pankratov;O. M. Mikhailik
通讯作者：
O. M. Mikhailik
影响因子：
3.4
作者：
Efimova, Olga;Hore, P. J.
通讯作者：
Hore, P. J.
影响因子：
2.6
作者：
Hanini, Raouia;Chatti, Abdelwaheb;Landoulsi, Ahmed
通讯作者：
Landoulsi, Ahmed