The human neurosecretome: extracellular vesicles and particles (EVPs) of the brain for intercellular communication, therapy, and liquid-biopsy applications.
The human neurosecretome: extracellular vesicles and particles (EVPs) of the brain for intercellular communication, therapy, and liquid-biopsy applications.
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DOI：
10.3389/fmolb.2023.1156821
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发表时间：
2023
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
新出现的证据表明，脑源性细胞外囊泡（EV）和颗粒（EP）可以穿过血脑屏障并介导神经元、星形胶质细胞、小胶质细胞和中枢神经系统（CNS）的其他细胞之间的通信。然而，对循环EV和EP（EVP）的分子景观和功能的完整理解仍然是知识上的主要差距。这主要是由于缺乏隔离和分离所有不同尺寸和低浮力密度的EVP的技术。在这篇综述中，我们的目标是提供一个全面的了解神经分泌组，包括细胞外囊泡，携带分子签名的大脑在其微环境和体循环。我们讨论了EVP的生物起源，它们的功能，细胞与细胞的通讯，过去和新兴的分离技术，治疗方法和液体活检应用。重要的是要强调，景观的EVP是在一个不断的演变状态，因此，我们不仅讨论了过去的文献和目前的景观的EVP，但我们也推测如何新的EVP可能有助于成瘾，抑郁症，精神病，神经退行性疾病的病因，并在真实的时间监测的“活的大脑”援助。总的来说，神经分泌组是我们在这里介绍的一个概念，以体现其功能和疾病发病机制的大脑循环颗粒的纲要。最后，为了包含所有细胞外颗粒，我们使用了由国际细胞外囊泡学会（ISEV）定义的术语EVP。
Emerging evidence suggests that brain derived extracellular vesicles (EVs) and particles (EPs) can cross blood-brain barrier and mediate communication among neurons, astrocytes, microglial, and other cells of the central nervous system (CNS). Yet, a complete understanding of the molecular landscape and function of circulating EVs & EPs (EVPs) remain a major gap in knowledge. This is mainly due to the lack of technologies to isolate and separate all EVPs of heterogeneous dimensions and low buoyant density. In this review, we aim to provide a comprehensive understanding of the neurosecretome, including the extracellular vesicles that carry the molecular signature of the brain in both its microenvironment and the systemic circulation. We discuss the biogenesis of EVPs, their function, cell-to-cell communication, past and emerging isolation technologies, therapeutics, and liquid-biopsy applications. It is important to highlight that the landscape of EVPs is in a constant state of evolution; hence, we not only discuss the past literature and current landscape of the EVPs, but we also speculate as to how novel EVPs may contribute to the etiology of addiction, depression, psychiatric, neurodegenerative diseases, and aid in the real time monitoring of the “living brain”. Overall, the neurosecretome is a concept we introduce here to embody the compendium of circulating particles of the brain for their function and disease pathogenesis. Finally, for the purpose of inclusion of all extracellular particles, we have used the term EVPs as defined by the International Society of Extracellular Vesicles (ISEV).
影响因子：
2.8
作者：
Rana R;Sharma S;Ganguly NK
通讯作者：
Ganguly NK
影响因子：
4.7
作者：
Borodinsky LN;Belgacem YH;Swapna I;Sequerra EB
通讯作者：
Sequerra EB