Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.
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DOI：
10.1016/j.immuni.2015.04.019
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发表时间：
2015-05-19
期刊：
影响因子：
32.4
通讯作者：
Kwon, Douglas S.
中科院分区：
文献类型：
--
作者：
Anahtar, Melis N.;Byme, Elizabeth H.;Doherty, Kathleen E.;Bowman, Brittany A.;Yamamoto, Hidemi S.;Soumillon, Magali;Padavattan, Nikita;Ismail, Nasreen;Moodley, Amber;Sabatini, Mary E.;Ghebremichael, Musie S.;Nusbaum, Chad;Huttenhower, Curtis;Virgin, Herbert W.;Ndung'u, Thumbi;Dong, Krista L.;Walker, Bruce D.;Fichorova, Raina N.;Kwon, Douglas S.
乳杆菌在女性生殖道中的定植被认为是维持生殖器健康的关键。然而，关于生殖器微生物群如何影响宿主免疫功能和调节疾病易感性知之甚少。我们研究了一组无症状的南非年轻女性，发现大多数参与者的生殖器社区具有低乳酸菌丰度和高生态多样性。在横断面和纵向分析中，高多样性社区与生殖器促炎细胞因子浓度密切相关。转录谱分析表明，生殖器抗原呈递细胞通过Toll样受体4信号传导原位感知革兰氏阴性细菌产物，通过激活NF-κB信号传导途径和通过趋化因子产生募集淋巴细胞促进生殖器炎症。我们的研究提出了一种机制，通过这种机制，宫颈阴道微生物群影响生殖器炎症，从而可能影响女性的生殖健康，包括她感染艾滋病毒的风险。
Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. However, little is known about how genital microbiota influence host immune function and modulate disease susceptibility. We studied a cohort of asymptomatic young South African women and found that the majority of participants had genital communities with low Lactobacillus abundance and high ecological diversity. High diversity communities strongly correlated with genital pro-inflammatory cytokine concentrations in both cross-sectional and longitudinal analyses. Transcriptional profiling suggested that genital antigen presenting cells sense gram-negative bacterial products in situ via Toll-like receptor 4 signaling, contributing to genital inflammation through activation of the NF-κB signaling pathway and recruitment of lymphocytes by chemokine production. Our study proposes a mechanism by which cervicovaginal microbiota impact genital inflammation and thereby may affect a woman's reproductive health, including her risk of acquiring HIV.
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影响因子：
2.1
作者：
Cule, Erika;De Iorio, Maria
通讯作者：
De Iorio, Maria
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
新型的阴道菌群定殖模型为杀生作用机理提供了新的见解。
影响因子：
6.4
作者：
Fichorova RN;Yamamoto HS;Delaney ML;Onderdonk AB;Doncel GF
通讯作者：
Doncel GF
影响因子：
3.7
作者：
Ghartey JP;Smith BC;Chen Z;Buckley N;Lo Y;Ratner AJ;Herold BC;Burk RD
通讯作者：
Burk RD
影响因子：
3.7
作者：
Bradshaw CS;Walker J;Fairley CK;Chen MY;Tabrizi SN;Donovan B;Kaldor JM;McNamee K;Urban E;Walker S;Currie M;Birden H;Bowden F;Garland S;Pirotta M;Gurrin L;Hocking JS
通讯作者：
Hocking JS