Prevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women.
Prevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women.
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DOI：
10.1371/journal.pone.0057688
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hocking JS
中科院分区：
文献类型：
--
作者：
Bradshaw CS;Walker J;Fairley CK;Chen MY;Tabrizi SN;Donovan B;Kaldor JM;McNamee K;Urban E;Walker S;Currie M;Birden H;Bowden F;Garland S;Pirotta M;Gurrin L;Hocking JS
确定澳大利亚年轻性活跃妇女细菌性阴道病（BV）的患病率和发病率以及危险因素。从初级保健诊所招募了1 093名16-25岁的妇女。参与者完成了3个月的问卷调查和自我收集的阴道涂片6个月，为期12个月。主要终点为Nugent评分= 7-10（BV），次要终点为NS = 4-10（异常植物群[AF]）。 得出BV和AF患病率估计值和95%置信区间（95%CI），计算校正比值比（AOR）以探讨流行病学与BV和AF的关系。比例风险回归模型用于检查与BV和AF事件相关的因素。基线时，129名女性有BV [11.8%]，（95%CI：9.4-14.2）]和188例AF（17.2%; 15.1-19.5）。BV流行与最近有女性伴侣[AOR = 2.1; 1.0-4.4]和缺乏高等教育[AOR = 1.9; 1.2-3.0]相关;使用含雌激素的避孕药（OCC）与风险降低相关[AOR = 0.6; 0.4-0.9]。 房颤的患病率与相同的因素相关，另外与12个月内>5名男性伴侣（MSP）[AOR = 1.8; 1.2-2.5）]和沙眼衣原体或生殖道支原体检测[AOR = 2.1; 1.0-4.5]相关。 有82例BV事件（9.4%;7.7-11.7/100人-年）和129例AF事件（14.8%; 12.5-17.6/100人-年）。BV和AF事件分别与新的MSP相关[校正率比（ARR）= 1.5; 1.1-2.2和ARR = 1.5; 1.1-2.0]。 OCC使用与AF事件风险降低相关[ARR = 0.7; 0.5-1.0]。 本文介绍了主要从初级保健诊所招募的澳大利亚年轻女性的大型前瞻性队列的BV和AF患病率和发病率估计。这些数据支持性活动与BV和AF的发展密切相关，使用OCC与风险降低相关的概念。
To determine prevalence and incidence of bacterial vaginosis (BV) and risk factors in young sexually-active Australian women. 1093 women aged 16–25 years were recruited from primary-care clinics. Participants completed 3-monthly questionnaires and self-collected vaginal smears 6-monthly for 12-months. The primary endpoint was a Nugent Score = 7–10 (BV) and the secondary endpoint was a NS = 4–10 (abnormal flora [AF]). BV and AF prevalence estimates and 95% confidence intervals (95%CI) were derived, and adjusted odds ratios (AOR) calculated to explore epidemiological associations with prevalent BV and AF. Proportional-hazards regression models were used to examine factors associated with incident BV and AF. At baseline 129 women had BV [11.8% (95%CI: 9.4–14.2)] and 188 AF (17.2%; 15.1–19.5). Prevalent BV was associated with having a recent female partner [AOR = 2.1; 1.0–4.4] and lack of tertiary-education [AOR = 1.9; 1.2–3.0]; use of an oestrogen-containing contraceptive (OCC) was associated with reduced risk [AOR = 0.6; 0.4–0.9]. Prevalent AF was associated with the same factors, and additionally with >5 male partners (MSP) in 12-months [AOR = 1.8; 1.2–2.5)], and detection of C.trachomatis or M.genitalium [AOR = 2.1; 1.0–4.5]. There were 82 cases of incident BV (9.4%;7.7–11.7/100 person-years) and 129 with incident AF (14.8%; 12.5–17.6/100 person-years). Incident BV and AF were associated with a new MSP [adjusted rate ratio (ARR) = 1.5; 1.1–2.2 and ARR = 1.5; 1.1–2.0], respectively. OCC-use was associated with reduced risk of incident AF [ARR = 0.7; 0.5–1.0]. This paper presents BV and AF prevalence and incidence estimates from a large prospective cohort of young Australian women predominantly recruited from primary-care clinics. These data support the concept that sexual activity is strongly associated with the development of BV and AF and that use of an OCC is associated with reduced risk.
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DOI：
10.1086/657320
发表时间：
2010-12-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brotman RM;Klebanoff MA;Nansel TR;Yu KF;Andrews WW;Zhang J;Schwebke JR
通讯作者：
Schwebke JR
影响因子：
17.1
作者：
Gajer P;Brotman RM;Bai G;Sakamoto J;Schütte UM;Zhong X;Koenig SS;Fu L;Ma ZS;Zhou X;Abdo Z;Forney LJ;Ravel J
通讯作者：
Ravel J
影响因子：
6.4
作者：
Hawes, SE;Hillier, SL;Holmes, KK
通讯作者：
Holmes, KK
影响因子：
3.6
作者：
Brotman RM;Ravel J;Cone RA;Zenilman JM
通讯作者：
Zenilman JM
影响因子：
1.4
作者：
Hellberg, D;Nilsson, S;Mårdh, PA
通讯作者：
Mårdh, PA