Size-dependent osteogenesis of black phosphorus in nanocomposite hydrogel scaffolds.
Size-dependent osteogenesis of black phosphorus in nanocomposite hydrogel scaffolds.
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DOI：
10.1002/jbm.a.37382
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发表时间：
2022-08
影响因子：
4.9
通讯作者：
Lu, Lichun
中科院分区：
文献类型：
--
作者：
Xu, Haocheng;Liu, Xifeng;Park, Sungjo;Terzic, Andre;Lu, Lichun
在骨组织工程中出现的一种有前途的新策略是将黑磷（BP）掺入聚合物支架中，制备具有生物相容性、降解可控性和成骨能力的纳米复合水凝胶平台。BP量子点是近年来兴起的一个新概念，它以其微小的结构和一系列优异的特性在BP家族中脱颖而出。在这项研究中，BP通过不同的剥离策略被加工成三种不同尺寸的纳米片，然后掺入到交联寡聚[聚（乙二醇）富马酸酯]（OPF）中，以产生用于骨再生的纳米复合水凝胶。三种不同的BP纳米片被指定为BP-L、BP-M和BP-S，相应的直径为242.3 ± 90.0、107.1 ± 47.9和18.8 ± 4.6 nm。MC 3 T3前成骨细胞的降解动力学和体外成骨能力均依赖于BP的大小。BP在体外具有可控的降解速率，降解速率随着纳米片尺寸的减小而增大，并伴有磷酸盐的释放。与单独的OPF水凝胶相比，加入所有BP纳米片的水凝胶的成骨能力得到促进。最小的BP量子点在增强MC 3 T3细胞行为方面显示出最佳效果，包括在OPF水凝胶上的铺展、分布、增殖和分化。这些结果证实了将BP量子点补充到OPF纳米复合水凝胶支架中可以潜在地应用于骨缺损的修复。
A promising new strategy emerged in bone tissue engineering is to incorporate black phosphorus (BP) into polymer scaffolds, fabricating nanocomposite hydrogel platforms with biocompatibility, degradation controllability, and osteogenic capacity. BP quantum dot is a new concept and stands out recently among the BP family due to its tiny structure and a series of excellent characteristics. In this study, BP was processed into nanosheets of three different sizes via different exfoliation strategies and then incorporated into cross-linkable oligo[poly(ethylene glycol) fumarate] (OPF) to produce nanocomposite hydrogels for bone regeneration. The three different BP nanosheets were designated as BP-L, BP-M, and BP-S, with a corresponding diameter of 242.3 ± 90.0, 107.1 ± 47.9, and 18.8 ± 4.6 nm. The degradation kinetics and osteogenic capacity of MC3T3 pre-osteoblasts in vitro were both dependent on the BP size. BP exhibited a controllable degradation rate, which increased with the decrease of the size of the nanosheets, coupled with the release of phosphate in vitro. The osteogenic capacity of the hydrogels was promoted with the addition of all BP nanosheets, compared with OPF hydrogel alone. The smallest BP quantum dots was shown to be optimal in enhancing MC3T3 cell behaviors, including spreading, distribution, proliferation, and differentiation on the OPF hydrogels. These results reinforced that the supplementation of BP quantum dots into OPF nanocomposite hydrogel scaffolds could potentially find application in the restoration of bone defects.
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影响因子：
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