Evidence of exposure to C. burnetii among slaughterhouse workers in western Kenya.
Evidence of exposure to C. burnetii among slaughterhouse workers in western Kenya.
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DOI：
10.1016/j.onehlt.2021.100305
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Fèvre EM
中科院分区：
文献类型：
--
作者：
Cook EAJ;de Glanville WA;Thomas LF;Kiyong'a A;Kivali V;Kariuki S;Bronsvoort BMC;Fèvre EM
Q热，由C.贝氏体，已报告在世界各地的屠宰场工人。报告最多的血清阳性风险因素是工人在屠宰场的作用。本研究调查了C抗体血清阳性率和危险因素。在肯尼亚西部的屠宰场工人中发现了贝氏体，以填补与东非这种新出现的疾病有关的数据空白。2012年2月至11月期间，从研究区域所有同意的屠宰场招募个体。从参与的工人那里收集有关人口统计数据、屠宰的动物和在屠宰场中的作用的信息。对血清样本进行抗C.使用商业ELISA检测贝氏体，并使用多水平逻辑回归分析鉴定与血清阳性相关的风险因素。屠宰场工人（n = 566）从84反刍动物屠宰场在肯尼亚西部招募。C.贝氏体为37.1%（95%置信区间（CI）33.2-41.2%）。对C.贝氏血清阳性包括：男性工人与女性工人相比，OR值为5.40（95% CI 1.38-21.22），屠宰牛和小反刍动物与只屠宰牛的工人相比，OR值为1.52（95% CI 1.06-2.19）。此外，屠宰场中的特定角色与血清阳性几率增加相关，包括清洁屠宰场，OR 3.98（95% CI 1.39-11.43）;清洁肠道，OR 3.24（95% CI 1.36-7.73）;和剥皮胴体OR 2.63（95% CI 1.46-4.75）相比，作为屠宰工或工头。我们发现，屠宰场工人有较高的血清抗体阳性率的C。Burnetii与来自同一地区的普通人群中的已发表值进行比较。因此，屠宰场工人是东非环境中的一个职业风险群体。与内脏和体液接触较多的工人暴露于C的风险较高。伯内特氏菌对工人进行教育可能会减少传播，但另一种方法可能是考虑高危人群接种疫苗的好处。
Q fever, caused by C. burnetii, has been reported in slaughterhouse workers worldwide. The most reported risk factor for seropositivity is the workers' role in the slaughterhouse. This study examined the seroprevalence and risk factors for antibodies to C. burnetii in slaughterhouse workers in western Kenya to fill a data gap relating to this emerging disease in East Africa. Individuals were recruited from all consenting slaughterhouses in the study area between February and November 2012. Information was collected from participating workers regarding demographic data, animals slaughtered and role in the slaughterhouse. Sera samples were screened for antibodies to C. burnetii using a commercial ELISA and risk factors associated with seropositivity were identified using multi-level logistic regression analysis. Slaughterhouse workers (n = 566) were recruited from 84 ruminant slaughterhouses in western Kenya. The seroprevalence of antibodies to C. burnetii was 37.1% (95% Confidence Interval (CI) 33.2–41.2%). The risk factors identified for C. burnetii seropositivity included: male workers compared to female workers, odds ratio (OR) 5.40 (95% CI 1.38–21.22); slaughtering cattle and small ruminants compared to those who only slaughtered cattle, OR 1.52 (95% CI 1.06–2.19). In addition, specific roles in the slaughterhouse were associated with increased odds of being seropositive, including cleaning the slaughterhouse, OR 3.98 (95% CI 1.39–11.43); cleaning the intestines, OR 3.24 (95% CI 1.36–7.73); and flaying the carcass OR 2.63 (95% CI 1.46–4.75) compared to being the slaughterman or foreman. We identified that slaughterhouse workers have a higher seroprevalence of antibodies to C. burnetii compared to published values in the general population from the same area. Slaughterhouse workers therefore represent an occupational risk group in this East African setting. Workers with increased contact with the viscera and fluids are at higher risk for exposure to C. burnetii. Education of workers may reduce transmission, but an alternative approach may be to consider the benefits of vaccination in high-risk groups.
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