Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection.
Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection.
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在最近和远程记忆中，海马波及其与默认模式网络的协调对话。
DOI：
10.1016/j.neuron.2021.06.020
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发表时间：
2021-09-01
期刊：
影响因子：
16.2
通讯作者：
Malach R
中科院分区：
文献类型：
--
作者：
Norman Y;Raccah O;Liu S;Parvizi J;Malach R
海马波纹是由海马神经元组装产生的显著同步事件。迄今为止，涟漪主要与啮齿动物的导航记忆和人类的短期情景回忆有关。在这里，我们揭示了不同的配置文件的涟漪活动在人类海马在检索最近和远程自传体事件和语义事实。我们发现，与对照组相比，在报告回忆之前，涟漪率显着增加。多个海马部位的涟漪活动模式对记忆类型表现出显着的特异性。有趣的是，这些涟漪模式揭示了一个语义化的维度，其中与自传内容相关的模式变得与语义记忆相似，作为记忆年龄的函数。最后，在回忆过程中，广泛分布在新皮层的位点表现出涟漪耦合激活，在默认模式网络中发现了最强的激活。因此，我们的研究结果揭示了一个关键的作用，海马波纹在编排跨大规模的网络参与有意识的回忆海马皮质通信。Norman等人报道，当患者回忆过去的自传体事件时，同步海马爆发（涟漪）选择性地出现。这些涟漪形成的空间模式与语义记忆模式越来越相似，记忆越遥远。研究结果证明了涟漪在协调人脑记忆中的关键作用。
Hippocampal ripples are prominent synchronization events generated by hippocampal neuronal assemblies. To date, ripples have been primarily associated with navigational memory in rodents and shortterm episodic recollections in humans. Here, we uncover different profiles of ripple activity in the human hippocampus during the retrieval of recent and remote autobiographical events and semantic facts. We found that the ripple rate increased significantly before reported recall compared to control conditions. Patterns of ripple activity across multiple hippocampal sites demonstrated remarkable specificity for memory type. Intriguingly, these ripple patterns revealed a semantization dimension, in which patterns associated with autobiographical contents become similar to those of semantic memory as a function of memory age. Finally, widely distributed sites across the neocortex exhibited ripple-coupled activations during recollection, with the strongest activation found within the default mode network. Our results thus reveal a key role for hippocampal ripples in orchestrating hippocampal-cortical communication across large-scale networks involved in conscious recollection. Norman et al. report that synchronous hippocampal bursts (ripples) selectively emerge when patients recall past autobiographical events. Those ripples form spatial patterns that become increasingly similar to semantic-memory patterns, the more remote the memory. The results demonstrate the pivotal role of ripples in coordinating recollections in the human brain.
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影响因子：
2.7
作者：
Ehinger, Benedikt, V;Dimigen, Olaf
通讯作者：
Dimigen, Olaf
DOI：
10.1073/pnas.1721714115
发表时间：
2018-05-01
影响因子：
11.1
作者：
Daitch, Amy L.;Parvizi, Josef
通讯作者：
Parvizi, Josef
影响因子：
56.9
作者：
Fernandez-Ruiz, Antonio;Oliva, Azahara;Buzsaki, Gyorgy
通讯作者：
Buzsaki, Gyorgy
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
2.6
作者：
BARR, WB;GOLDBERG, E;NOVELLY, RA
通讯作者：
NOVELLY, RA