The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential.
The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential.
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DOI：
10.1289/ehp.0800319
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发表时间：
2009-07
影响因子：
10.4
通讯作者：
Nel AE
中科院分区：
文献类型：
--
作者：
Li N;Wang M;Bramble LA;Schmitz DA;Schauer JJ;Sioutas C;Harkema JR;Nel AE
已证明环境颗粒物（PM）可作为过敏致敏的佐剂。颗粒表面具有氧化还原活性的有机化学物质在PM对健康的不良影响中起重要作用，并可能根据其扰乱免疫系统氧化还原平衡的潜力决定不同颗粒类型的佐剂效应。
我们确定了环境细颗粒物与超细颗粒物（UFPs）的佐剂效应是否与其促氧化潜力相关。
我们建立了一种鼻内致敏模型，该模型使用环境PM作为对卵清蛋白（OVA）致敏的潜在佐剂，这增强了OVA二次激发诱导过敏性气道炎症的能力。
多环芳烃（PAH）含量更高且氧化电位更高的UFPs比细颗粒物更容易增强OVA致敏。这表现为OVA二次激发时过敏性炎症增强，导致从鼻甲一直到小肺气道的嗜酸性炎症和黏液样增生。巯基抗氧化剂N - 乙酰半胱氨酸能够抑制其中一些致敏事件。
环境UFPs的佐剂效应由其氧化电位决定，这可能在改变黏膜免疫系统的氧化还原平衡中起作用。
It has been demonstrated that ambient particulate matter (PM) can act as an adjuvant for allergic sensitization. Redox-active organic chemicals on the particle surface play an important role in PM adverse health effects and may determine the adjuvant effect of different particle types according to their potential to perturb redox equilibrium in the immune system. We determined whether the adjuvant effect of ambient fine particles versus ultrafine particles (UFPs) is correlated to their prooxidant potential. We have established an intranasal sensitization model that uses ambient PM as a potential adjuvant for sensitization to ovalbumin (OVA), which enhances the capacity for secondary OVA challenge to induce allergic airway inflammation. UFPs with a greater polycyclic aromatic hydrocarbon (PAH) content and higher oxidant potential enhanced OVA sensitization more readily than did fine particles. This manifests as enhanced allergic inflammation upon secondary OVA challenge, leading to eosinophilic inflammation and mucoid hyperplasia starting at the nasal turbinates all the way down to the small pulmonary airways. The thiol antioxidant N-acetyl cysteine was able to suppress some of these sensitization events. The adjuvant effects of ambient UFP is determined by their oxidant potential, which likely plays a role in changing the redox equilibrium in the mucosal immune system.
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超铁颗粒在空气颗粒质量与心血管健康之间关联中的潜在作用。
影响因子：
10.4
作者：
Delfino RJ;Sioutas C;Malik S
通讯作者：
Malik S
DOI：
10.1165/ajrcmb.25.4.4515
发表时间：
2001-10-01
影响因子：
6.4
作者：
Bonvallot, V;Baeza-Squiban, A;Marano, F
通讯作者：
Marano, F
影响因子：
3.5
作者：
Kadkhoda, K;Pourfathollah, AA;Kazemnejad, A
通讯作者：
Kazemnejad, A
DOI：
10.1089/jam.2006.19.74
发表时间：
2006-03-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Kreyling, WG;Semmler-Behnke, M;Möller, W
通讯作者：
Möller, W
影响因子：
14.2
作者：
Chan, Ray Chun-Fai;Wang, Meiying;Nel, Andre E.
通讯作者：
Nel, Andre E.