Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?
Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?
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DOI：
10.1186/alzrt276
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Potter WZ
中科院分区：
文献类型：
--
作者：
Merlo Pich E;Jeromin A;Frisoni GB;Hill D;Lockhart A;Schmidt ME;Turner MR;Mondello S;Potter WZ
本文综述了磁共振成像（MRI）作为一种神经影像学方法在阿尔茨海默病新疗法开发中的应用前景。这些考虑是在最近的一次威康信托会议的圆桌会议上产生的，与会者包括来自学术界和工业界的专家。一致认为MRI（结构或功能）可用作诊断、评估疾病状态恶化、监测血管病理学和对临床试验人群进行分层。人们还认为，MRI的实施处于起步阶段，需要更多的证据与疾病状态的关联，重新测试的数据，更好的标准化在多个临床站点，并在多模式方法，包括其他成像技术，如正电子发射断层扫描，脑电图，脑磁图的应用。
This review provides perspectives on the utility of magnetic resonance imaging (MRI) as a neuroimaging approach in the development of novel treatments for Alzheimer’s disease. These considerations were generated in a roundtable at a recent Wellcome Trust meeting that included experts from academia and industry. It was agreed that MRI, either structural or functional, could be used as a diagnostic, for assessing worsening of disease status, for monitoring vascular pathology, and for stratifying clinical trial populations. It was agreed also that MRI implementation is in its infancy, requiring more evidence of association with the disease states, test-retest data, better standardization across multiple clinical sites, and application in multimodal approaches which include other imaging technologies, such as positron emission tomography, electroencephalography, and magnetoencephalography.
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影响因子：
3.7
作者：
Dyrba M;Ewers M;Wegrzyn M;Kilimann I;Plant C;Oswald A;Meindl T;Pievani M;Bokde AL;Fellgiebel A;Filippi M;Hampel H;Klöppel S;Hauenstein K;Kirste T;Teipel SJ;EDSD study group
通讯作者：
EDSD study group
DOI：
10.3233/jad-2012-112165
发表时间：
2012
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Gold BT;Jiang Y;Powell DK;Smith CD
通讯作者：
Smith CD
影响因子：
9.9
作者：
Chhatwal, Jasmeer P.;Schultz, Aaron P.;Sperling, Reisa A.
通讯作者：
Sperling, Reisa A.
影响因子：
38.1
作者：
Frisoni, Giovanni B.;Fox, Nick C.;Jack, Clifford R., Jr.;Scheltens, Philip;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
4.2
作者：
Johnson, S. C.;Schmitz, T. W.;Alexander, G. E.
通讯作者：
Alexander, G. E.