The clinical use of structural MRI in Alzheimer disease.
The clinical use of structural MRI in Alzheimer disease.
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DOI：
10.1038/nrneurol.2009.215
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发表时间：
2010-02
影响因子：
38.1
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Frisoni, Giovanni B.;Fox, Nick C.;Jack, Clifford R., Jr.;Scheltens, Philip;Thompson, Paul M.
基于磁共振的结构成像是疑似阿尔茨海默痴呆患者临床评估的一个组成部分。关于阿尔茨海默病从临床前到明显阶段的结构标志物变化的自然历史的前瞻性数据正在从根本上改变这种疾病的概念化方式，并将影响其未来的诊断和治疗。内侧颞叶结构萎缩现在被认为是轻度认知功能障碍阶段的有效诊断标志。结构成像也包括在最流行的非阿尔茨海默氏痴呆症的诊断标准，反映其在鉴别诊断的价值。此外，全脑和海马萎缩率是神经退行性变的敏感标志物，并且越来越多地用作潜在疾病改善疗法试验的结果指标。目前，大型多中心研究正在调查其他影像学和非影像学标记物在诊断和监测进展中作为临床评估辅助指标的价值。通过采集和分析方法的标准化，以及通过开发用于自动评估的稳健算法，结构成像和其他标记物的实用性将得到提高。
Structural imaging based on magnetic resonance is an integral part of the clinical assessment of patients with suspected Alzheimer dementia. Prospective data on the natural history of change in structural markers from preclinical to overt stages of Alzheimer disease are radically changing how the disease is conceptualized, and will influence its future diagnosis and treatment. Atrophy of medial temporal structures is now considered to be a valid diagnostic marker at the mild cognitive impairment stage. Structural imaging is also included in diagnostic criteria for the most prevalent non-Alzheimer dementias, reflecting its value in differential diagnosis. In addition, rates of whole-brain and hippocampal atrophy are sensitive markers of neurodegeneration, and are increasingly used as outcome measures in trials of potentially disease-modifying therapies. Large multicenter studies are currently investigating the value of other imaging and nonimaging markers as adjuncts to clinical assessment in diagnosis and monitoring of progression. The utility of structural imaging and other markers will be increased by standardization of acquisition and analysis methods, and by development of robust algorithms for automated assessment.
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影响因子：
4.2
作者：
Cardenas, V. A.;Chao, L. L.;Studholme, C.;Yaffe, K.;Miller, B. L.;Madison, C.;Buckley, S. T.;Mungas, D.;Schuff, N.;Weiner, M. W.
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影响因子：
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影响因子：
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作者：
Chételat, G;Landeau, B;Baron, JC
通讯作者：
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作者：
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