Enhancing signals of microfluidic impedance cytometry through optimization of microelectrode array

Enhancing signals of microfluidic impedance cytometry through optimization of microelectrode array
复制标题

通过优化微电极阵列增强微流控阻抗细胞术的信号

DOI:
10.1002/elps.202100351
复制
发表时间:
2022-03
期刊:
影响因子:
2.9
通讯作者:
Honglong Chang
Honglong Chang
中科院分区:
生物学3区
文献类型:
--
作者:
Chenyang Zhou;Hailong Shen;Huicheng Feng;Zhibin Yan;Bowen Ji;Xichen Yuan;Ruirong Zhang;Honglong Chang

文献摘要

参考文献

相似文献

微流控阻抗分析技术在生物医学诊断中具有重要的应用价值。然而,相邻微电极之间的串扰强烈地削弱了阻抗信号。据此,我们提出了一种新的微流控阻抗细胞仪组成的传感电极和接地电极(GNDs)。模拟结果显示,与没有GNDs相比,GNDs的信号增强了五倍以上。我们还发现,在一个高频率和在低频率的阻抗之间的线性相关性的微粒尺寸的变化而变化,这可以用于微粒分类。该研究为微流控阻抗分析中的微电极优化和信号处理提供了参考。
Microfluidic impedance cytometry shows a great value in biomedical diagnosis. However, the crosstalk between neighboring microelectrodes strongly weakens the impedance signal. Hereby, we demonstrate a novel microfluidic impedance cytometer consisted of sensing electrodes and ground electrodes (GNDs). The simulation reveals a signal enhancement by more than five times with GNDs compared to that without ones. We also found that the linear correlation between the impedance at a high frequency and that at a low frequency varies as microparticle size changes, which can be used for microparticle classification. The study can help with microelectrode optimization and signal processing for microfluidic impedance analysis.
DOI: 10.1038/s41698-017-0015-0
发表时间: 2017
影响因子: 7.9
作者:
Renier C;Pao E;Che J;Liu HE;Lemaire CA;Matsumoto M;Triboulet M;Srivinas S;Jeffrey SS;Rettig M;Kulkarni RP;Di Carlo D;Sollier-Christen E
通讯作者: Sollier-Christen E
DOI: 10.1109/transducerseurosenso43411.2019
发表时间: 2019-06
期刊: --
影响因子: --
作者:
通讯作者: --
DOI: 10.3390/s19153366
发表时间: 2019-08-01
期刊: SENSORS
影响因子: 3.9
作者:
Claudel, Julien;De Araujo, Arthur Luiz Alves;Kourtiche, Djilali
通讯作者: Kourtiche, Djilali
DOI: 10.1063/1.3117216
发表时间: 2009-05-01
影响因子: 3.2
作者:
Abdelgawad, Mohamed;Park, Philip;Wheeler, Aaron R.
通讯作者: Wheeler, Aaron R.
DOI: 10.1039/b505088j
发表时间: 2005-01-01
期刊: LAB ON A CHIP
影响因子: 6.1
作者:
Choi, S;Park, JK
通讯作者: Park, JK