Enhancing signals of microfluidic impedance cytometry through optimization of microelectrode array
Enhancing signals of microfluidic impedance cytometry through optimization of microelectrode array
复制标题
通过优化微电极阵列增强微流控阻抗细胞术的信号
DOI:
10.1002/elps.202100351
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发表时间:
2022-03
期刊:
影响因子:
2.9
通讯作者:
Honglong Chang
中科院分区:
文献类型:
--
作者:
Chenyang Zhou;Hailong Shen;Huicheng Feng;Zhibin Yan;Bowen Ji;Xichen Yuan;Ruirong Zhang;Honglong Chang
Microfluidic impedance cytometry shows a great value in biomedical diagnosis. However, the crosstalk between neighboring microelectrodes strongly weakens the impedance signal. Hereby, we demonstrate a novel microfluidic impedance cytometer consisted of sensing electrodes and ground electrodes (GNDs). The simulation reveals a signal enhancement by more than five times with GNDs compared to that without ones. We also found that the linear correlation between the impedance at a high frequency and that at a low frequency varies as microparticle size changes, which can be used for microparticle classification. The study can help with microelectrode optimization and signal processing for microfluidic impedance analysis.
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DOI:
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