GABAergic neural activity involved in salicylate-induced auditory cortex gain enhancement.
GABAergic neural activity involved in salicylate-induced auditory cortex gain enhancement.
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DOI：
10.1016/j.neuroscience.2011.04.073
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发表时间：
2011-08-25
期刊：
影响因子：
3.3
通讯作者：
Sun, W.
中科院分区：
文献类型：
--
作者：
Lu, J.;Lobarinas, E.;Deng, A.;Goodey, R.;Stolzberg, D.;Salvi, R. J.;Sun, W.
虽然高剂量的水杨酸钠损害耳蜗功能，但它矛盾地增强了听觉皮层（AC）中的声音诱发活动，并增强了与过度兴奋和听觉过敏相关的声惊吓反射反应、神经和行为指标。为了探讨水杨酸诱导的过度兴奋和“中枢增益增加”的神经机制，我们研究了γ-氨基丁酸（GABA）受体激动剂和拮抗剂对水杨酸诱导的AC和惊吓反射反应中的过度兴奋的影响。与我们以前的研究结果一致，局部或全身应用水杨酸盐显着增加了声音诱发的AC神经活动的幅度，但一般减少AC的自发活动。全身注射水杨酸也显着增加声惊吓反射。S-巴氯芬或R-巴氯芬，GABA-B激动剂，抑制声音诱发的AC神经放电率和局部场电位，也抑制水杨酸诱导的AC场电位的增强和声学惊吓反射。局部应用氨己烯酸，提高GABA在大脑中的浓度，抑制水杨酸诱导的AC放电率的增强。全身注射氨己烯酸也减少水杨酸引起的声惊吓反射增强。总的来说，这些结果表明，水杨酸诱导的声音诱发的行为和神经活动过度可能是由于水杨酸诱导的抑制GABA能抑制AC。
Although high doses of sodium salicylate impair cochlear function, it paradoxically enhances sound-evoked activity in the auditory cortex (AC) and augments acoustic startle reflex responses, neural and behavioral metrics associated with hyperexcitability and hyperacusis. To explore the neural mechanisms underlying salicylate-induced hyperexcitability and “increased central gain”, we examined the effects of γ-aminobutyric acid (GABA) receptor agonists and antagonists on salicylate-induced hyperexcitability in the AC and startle reflex responses. Consistent with our previous findings, local or systemic application of salicylate significantly increased the amplitude of sound-evoked AC neural activity, but generally reduced spontaneous activity in the AC. Systemic injection of salicylate also significantly increased the acoustic startle reflex. S-baclofen or R-baclofen, GABA-B agonists, which suppressed sound-evoked AC neural firing rate and local field potentials, also suppressed the salicylate-induced enhancement of the AC field potential and the acoustic startle reflex. Local application of vigabatrin, which enhances GABA concentration in the brain, suppressed the salicylate-induced enhancement of AC firing rate. Systemic injection of vigabatrin also reduced the salicylate-induced enhancement of acoustic startle reflex. Collectively, these results suggest that the sound-evoked behavioral and neural hyperactivity induced by salicylate may arise from a salicylate-induced suppression GABAergic inhibition in the AC.
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DOI：
10.1080/010503999424653
发表时间：
1999-01-01
期刊：
SCANDINAVIAN AUDIOLOGY
影响因子：
--
作者：
Anari, M;Axelsson, A;Magnusson, L
通讯作者：
Magnusson, L
影响因子：
2.9
作者：
HUNTER, KP;WILLOTT, JF
通讯作者：
WILLOTT, JF
阿司匹林代谢物水杨酸盐通过减少 GABA 能抑制增强大鼠海马 CA1 区神经元兴奋
影响因子：
4.7
作者：
Gong, Neng;Zhang, Min;Xu, Tian-Le
通讯作者：
Xu, Tian-Le
影响因子：
3.8
作者：
COX, CL;METHERATE, R;ASHE, JH
通讯作者：
ASHE, JH
影响因子：
4.2
作者：
Kumru, Hatice;Kofler, Markus;Vidal, Joan
通讯作者：
Vidal, Joan