Age-related changes in antioxidant enzymes related to hydrogen peroxide metabolism in rat inner ear.
Age-related changes in antioxidant enzymes related to hydrogen peroxide metabolism in rat inner ear.
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DOI：
10.1016/j.neulet.2009.08.015
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发表时间：
2009-10-16
影响因子：
2.5
通讯作者：
Henderson D
中科院分区：
文献类型：
--
作者：
Coling D;Chen S;Chi LH;Jamesdaniel S;Henderson D
氧化应激是衰老中的一个普遍因素，并与噪声诱导的耳蜗病理学有关。本研究测定了3月龄和24月龄Fisher-344大鼠过氧化氢(H_2O_2)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GPX)的活性，以及3月龄、12月龄和24月龄大鼠还原型谷胱甘肽(GSH)的氧化还原活性。耳蜗血管组织(螺旋韧带和血管纹)中的GPx活性增加，而耳蜗肌、感觉和前庭组织中的GPx活性无变化。血管组织的升高与年龄有关。我们观察到前庭组织的过氧化氢酶活性显著升高，蜗牛的过氧化氢酶活性有随年龄增加的趋势，但血管或感觉耳蜗组织没有变化。这些发现表明，耳蜗血管组织中GPX活性的增加可能是对谷胱甘肽减少和氧化还原状态下降的一种与年龄相关的补偿。
Oxidative stress is a pervasive factor in aging and has been implicated in noise-induced cochlear pathology. In this study, we measured the activities of two enzymes that catalyze the removal of hydrogen peroxide (H2O2), catalase and glutathione peroxidase (Gpx), in 3 and 24 month old Fisher-344 rats, and reduced and oxidized glutathione in 3, 12, and 24 month old rats. There was an increase in Gpx activity in vascular tissue (spiral ligament and stria vascularis), but no change in modiolar, sensory or vestibular tissue of the cochlea. The elevation in vascular tissue was age-related. We observed a significant elevation of catalase activity in vestibular tissue, a tendency for age-related elevation in the modiolus, but no change in vascular or sensory cochlear tissue. These findings suggest that increased Gpx activity in vascular cochlear tissue may be an age-related compensation for a decrease in glutathione and a decline in the redox state measured by the ratio of reduced to oxidized glutathione.
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影响因子：
2.9
作者：
REED, DJ;BABSON, JR;POTTER, DW
通讯作者：
POTTER, DW
影响因子：
--
作者：
JI, LL;DILLON, D;WU, E
通讯作者：
WU, E
DOI：
10.1016/s0378-4347(01)00298-5
发表时间：
2001-09-15
影响因子：
3
作者：
Dominick, PK;Cassidy, PB;Roberts, JC
通讯作者：
Roberts, JC
影响因子：
7.4
作者：
Coling, DE;Yu, KCY;Lalwani, AK
通讯作者：
Lalwani, AK
影响因子：
1.6
作者：
Sha, SH;Zajic, G;Schacht, J
通讯作者：
Schacht, J