Human blood-vessel-derived stem cells for tissue repair and regeneration.
Human blood-vessel-derived stem cells for tissue repair and regeneration.
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DOI：
10.1155/2012/597439
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发表时间：
2012
影响因子：
--
通讯作者：
Huard J
中科院分区：
文献类型：
--
作者：
Chen CW;Corselli M;Péault B;Huard J
具有相似发育潜力的多能干/祖细胞已从不同的人体组织/器官培养物中独立鉴定出来。对间充质前体的血管/血管周围起源的日益认识表明血管是成体干细胞/祖细胞的系统来源。我们的小组和其他实验室最近从成人组织的血管中分离出多种干/祖细胞亚群。血管的三个结构层：内膜、中膜和外膜中的每一层都包含至少一种前体细胞群，即分别是肌源性内皮细胞（MEC）、周细胞和外膜细胞（AC）。 MEC 和周细胞可以有效地再生受伤和营养不良的骨骼肌中的肌纤维，并改善心肌梗塞后的心脏功能。 ACs 在血管重塑和血管生成/血管生成中的应用已经得到检验。我们最近发现 MEC 和周细胞可以从低温储存的人类原代肌肉细胞培养物中纯化，进一步表明它们在个性化再生医学中的潜在应用。
Multipotent stem/progenitor cells with similar developmental potentials have been independently identified from diverse human tissue/organ cultures. The increasing recognition of the vascular/perivascular origin of mesenchymal precursors suggested blood vessels being a systemic source of adult stem/progenitor cells. Our group and other laboratories recently isolated multiple stem/progenitor cell subsets from blood vessels of adult human tissues. Each of the three structural layers of blood vessels: intima, media, and adventitia has been found to include at least one precursor population, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs), respectively. MECs and pericytes efficiently regenerate myofibers in injured and dystrophic skeletal muscles as well as improve cardiac function after myocardial infarction. The applications of ACs in vascular remodeling and angiogenesis/vasculogenesis have been examined. Our recent finding that MECs and pericytes can be purified from cryogenically banked human primary muscle cell culture further indicates their potential applications in personalized regenerative medicine.
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影响因子：
14
作者：
He, Wei;Nieponice, Alejandro;Soletti, Lorenzo;Hong, Yi;Gharaibeh, Burhan;Crisan, Mihaela;Usas, Arvydas;Peault, Bruno;Huard, Johnny;Wagner, William R.;Vorp, David A.
通讯作者：
Vorp, David A.
影响因子：
37.8
作者：
Farrington-Rock, C;Crofts, NJ;Canfield, AE
通讯作者：
Canfield, AE
影响因子：
2.6
作者：
Andreeva, ER;Pugach, IM;Orekhov, AN
通讯作者：
Orekhov, AN
影响因子：
37.8
作者：
Campagnolo P;Cesselli D;Al Haj Zen A;Beltrami AP;Kränkel N;Katare R;Angelini G;Emanueli C;Madeddu P
通讯作者：
Madeddu P
影响因子：
21.3
作者：
Dellavalle, Arianna;Sampaolesi, Maurilio;Cossu, Giulio
通讯作者：
Cossu, Giulio