The intimate relationships of mRNA decay and translation.

The intimate relationships of mRNA decay and translation.
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DOI:
10.1016/j.tig.2013.09.002
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发表时间:
2013-12
期刊:
影响因子:
11.4
通讯作者:
Jacobson, Allan
Jacobson, Allan
中科院分区:
生物学1区
文献类型:
--
作者:
Roy, Bijoyita;Jacobson, Allan

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mRNA 的衰减率及其翻译效率是真核基因表达的关键决定因素。尽管人们曾经认为 mRNA 稳定性和翻译效率直接相关,但这两个过程之间的相互关系要复杂得多。翻译损伤可以触发或拮抗单个 mRNA 的衰变,某些 mRNA 半衰期的改变甚至可以改变翻译保真度。在这篇综述中,我们考虑 mRNA 翻译和周转是否是 mRNA 生命周期的不同阶段或重叠阶段,然后讨论这两个过程在真核细胞中相互影响的多种方式中的一些。
The decay rate of an mRNA and the efficiency with which it is translated are key determinants of eukaryotic gene expression. Although it was once thought that mRNA stability and translational efficiency were directly linked, the interrelationships between the two processes are considerably more complex. The decay of individual mRNAs can be triggered or antagonized by translational impairment, and alterations in the half-life of certain mRNAs can even alter translational fidelity. In this review, we consider whether mRNA translation and turnover are distinct or overlapping phases of an mRNA life cycle, and then address some of the many ways in which the two processes influence each other in eukaryotic cells.
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