The intimate relationships of mRNA decay and translation.
The intimate relationships of mRNA decay and translation.
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DOI:
10.1016/j.tig.2013.09.002
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发表时间:
2013-12
影响因子:
11.4
通讯作者:
Jacobson, Allan
中科院分区:
文献类型:
--
作者:
Roy, Bijoyita;Jacobson, Allan
The decay rate of an mRNA and the efficiency with which it is translated are key determinants of eukaryotic gene expression. Although it was once thought that mRNA stability and translational efficiency were directly linked, the interrelationships between the two processes are considerably more complex. The decay of individual mRNAs can be triggered or antagonized by translational impairment, and alterations in the half-life of certain mRNAs can even alter translational fidelity. In this review, we consider whether mRNA translation and turnover are distinct or overlapping phases of an mRNA life cycle, and then address some of the many ways in which the two processes influence each other in eukaryotic cells.
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