The impact of total enteral nutrition on distraction osteogenesis in a rat model
The impact of total enteral nutrition on distraction osteogenesis in a rat model
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全肠内营养对大鼠模型牵张成骨的影响
DOI：
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发表时间：
1996
影响因子：
6.2
通讯作者：
T. Badger
中科院分区：
文献类型：
--
作者：
C. Lumpkin;Jr. J. Aronson;X. Shen;G. Gao;R. Skinner;T. Badger
Limb lengthening by gradual mechanical distraction, termed distraction osteogenesis (DO), results in new bone formation. We have developed a rat tibial model for DO and have proceeded to study the effects of nutrition on this process. We have combined the intragastric diet delivery system of total enteral nutrition (TEN) with DO in the rat model. The first study was designed to address the weight loss associated with DO in dogs and patients. Rats in the chow + DO group lost 10% body weight over the 20‐day distraction period but gradually gained weight back to the preoperative level by the end of the 5th week of the bone consolidation period. In contrast, in the TEN + DO group, a weight gain was recorded during the 20‐day distraction phase. A second study was conducted to determine the effects of TEN on the rate and histology of regenerate bone formation. The weight changes replicated those seen in the first study. Standardized radiographs, taken on day 20, revealed increases (p > 0.003) in regenerate bone formation in the TEN group when compared with the chow group. Increased numbers of osteoclasts in the TEN group may indicate an accelerated entry into the remodeling phase of consolidation. Serum IGF‐I values, taken at day 20, did not differ between the groups. These results demonstrate that the nutritional support dramatically increased the mineralized bone formed over the 20‐day distraction period. (J Bone Miner Res 1996;11:962–969)
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性腺类固醇对大鼠稳态生长激素清除的影响。
影响因子：
4.8
作者：
Badger,TM;Millard,WJ;Owens,SM;LaRovere,J;O'Sullivan,D
通讯作者：
O'Sullivan,D
影响因子：
20.3
作者：
E. Canalis
通讯作者：
E. Canalis
DOI：
10.1016/b978-0-12-375098-3.50020-2
发表时间：
2000-04
影响因子：
1.6
作者：
E. Canalis;J. Pash;S. Varghese
通讯作者：
E. Canalis;J. Pash;S. Varghese
肾组织生长调节素-C/胰岛素样生长因子 I 与大鼠肾切除术后肾脏生长的关系。
影响因子：
4.8
作者：
Stiles,AD;Sosenko,IR;D'Ercole,AJ;Smith,BT
通讯作者：
Smith,BT
DOI：
10.1111/j.1530-0277.1991.tb00581.x
发表时间：
1991-08
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
M. Ronis;C. Lumpkin;Magnus Ingelman-Sundberg;T. M. Badger
通讯作者：
M. Ronis;C. Lumpkin;Magnus Ingelman-Sundberg;T. M. Badger