Melanotic oncocytic metaplasia of the nasopharynx as a benign mimicker of malignant melanoma: a case report.
Melanotic oncocytic metaplasia of the nasopharynx as a benign mimicker of malignant melanoma: a case report.
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DOI：
10.1186/1746-1596-5-5
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发表时间：
2010-01-14
影响因子：
2.6
通讯作者：
Morinaka S
中科院分区：
文献类型：
--
作者：
Kondo T;Mori K;Oka S;Morinaka S
摘要鼻咽部嗜酸细胞化生的黑色素变异是一种极为罕见的疾病。一位73岁的日本男性，因鼻塞和发冷而就诊。鼻镜检查发现双侧输卵管隆凸周围多发黑色结节。对结节进行活检以确定组织学。临床鉴别诊断为恶性黑色素瘤或血管瘤。镜下见嗜酸细胞肥大，细胞内有丰富的棕色颗粒，呈腺样分布。未见明显色素沉着，Fontana-Masson染色阳性，柏林蓝染色阴性，为黑色素。免疫组化上，也发现S100阳性HMB 45阴性树突状细胞。这种色素性的良性嗜酸细胞病变是非常罕见的，只有15例已在英文文献中报道。作为恶性黑色素瘤的良性模仿者，黑素细胞嗜酸细胞化生在临床上应始终予以考虑。
Melanotic variant of oncocytic metaplasia of the nasopharynx is an extremely rare condition. A 73-year-old Japanese man presented with nasal congestion and chill. Nasoscopic examination revealed multiple black nodules around the bilateral torus tubarius. The nodules were biopsied to determine the histology. The clinical differential diagnosis was malignant melanoma or hemangioma. Microscopically, there were oncocytic plump cells with abundant brown pigmented granules showing glandular pattern. No significant atypia was found. The pigment was positive for Fontana-Masson staining, and negative for Berlin blue staining, showing that it was melanin pigment. Immunohistochemically, S100-positive HMB45-negative dendritic cells were also found. Such a pigmented variant of benign oncocytic lesion is very rare, and only 15 cases have been reported in the English literature. As a benign mimicker of malignant melanoma, melanocytic oncocytic metaplasia should be always taken into consideration in the clinical setting.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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